ReviewDelineation of genetic predisposition to multifactorial disease: A general approach on the threshold of feasibility
References (44)
- et al.
The outlook for linkage research in psychiatric disorders
J. Psychiatr. Res
(1987) - et al.
Characterization of mutations in the factor VIII gene by direct sequencing of amplified genomic DNA
Genomics
(1990) DNA sequence variants in the Cγ, Aγ-δ- and β-globin genes of man
Cell
(1979)- et al.
Association of genetic variant of the glucose transporter with noninsulin-dependent diabetes mellitus
Lancet
(1988) - et al.
Direct sequencing of the gene for Maryland/German familial amyloidotic polyneuropathy type II and genotyping by allele-specific enzymatic amplification
Genomics
(1989) - et al.
Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
Genomics
(1989) - et al.
Characterization of PCR amplification of specific alleles
Anal. Biochem
(1990) - et al.
Direct sequencing of the activation peptide and the catalytic domains of the factor IX gene of six species
Genomics
(1990) - et al.
A method of sequencing without subcloning and its application to the identification of a novel ORF with a sequence suggestive of a transcriptional regulator in the water mold, Achlya ambisexualis
Genomics
(1990) - et al.
A novel method of detecting point mutations or polymorphisms and its application to population screening for carriers of phenylketonuria
Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia
A biochemical perspective of the polymerase chain reaction
Biochemistry
Allelic association of human dopamine D2 receptor gene in alcoholism
J. Am. Med. Assoc
Construction of a genetic linkage map in man using restriction fragment length polymorphisms
Am. J. Hum. Genet
Missense mutations and evolutionary conservation of amino acids: Evidence that many of the amino acids in factor IX function as “spacer” elements
Am. J. Hum. Genet
PCR amplification of specific alleles: A general method of rapidly detecting mutations, polymorphisms, and haplotypes
Estimating the population attributable risk for multiple risk factors using case-control data
Am. J. Epidemiol
Apolipoprotein A-I gene polymorphism and susceptibility of non-insulin-dependent diabetes mellitus
Am. J. Hum. Genet
Illegitimate transcription: Transcription of any gene in any cell type
An estimate of unique DNA sequence heterozygosity in the human genome
Hum. Genet
The CpG dinucleotide and human genetic disease
Hum. Genet
Estimation of genetic variation at the DNA level from restriction endonuclease data
Cited by (77)
VAPSE-based analysis: A two-phased candidate gene approach for elucidating genetic predisposition to complex disorders
2001, Mutation Research - Mutation Research GenomicsCitation Excerpt :Since most candidate genes will not prove to be associated with the primary disease(s) of interest, the “bread and butter” of VAPSE-based analysis is genotype-to-phenotype searches. Genotype-to-phenotype searches constitute a historical cohort analysis [1]. The “exposed” population is composed of individuals harboring a VAPSE and the “unexposed” population is comprised of patients who do not harbor the VAPSE.
Molecular genetic approaches to puerperal psychosis
2001, Progress in Brain ResearchComplexity and power in case-control association studies
2001, American Journal of Human GeneticsCitation Excerpt :However, the further improvement with correct classification as to high-risk or low-risk status illustrates the value of distinguishing the most important mutations. At one level, we can attempt to distinguish what Sobell et al. (1992) call VAPSEs (variations affecting protein sequence or expression) from silent allelic variation. At another level, single-locus substitutions at evolutionarily conserved sites might be separated from those at nonconserved sites.
Genetic variation in the B7-1 gene in patients with multiple sclerosis
2000, Journal of NeuroimmunologyChapter 2.1.4 Genetic association studies in behavioral neuroscience
1999, Techniques in the Behavioral and Neural SciencesGenetics of bipolar disorder
2019, Bipolar Disorder: The Science of Mental Health