Analysis of the human regulators of complement activation (RCA) gene cluster with yeast artificial chromosomes (YACs)☆
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Cited by (58)
Membrane Cofactor Protein
2018, The Complement FactsBook: Second EditionAlternative polyadenylation expands the mRNA isoform repertoire of human CD46
2017, GeneCitation Excerpt :Most likely CD46P1 IPA in intron 2 might serve as a means to prevent CD46P1 expression by inducing early polyadenylation, as our lack of detection of CD46P1 regions downstream exon 2 makes expression of full-length CD46P1 (exons 1–5) very rare at best. Intron 2 IPA might explain the so-far elusive detection of CD46P1 mRNA, despite possessing comparable promoter activity (Cui et al., 1993) and high homology to 5′ portion of CD46 (Hourcade et al., 1992). Future studies should test the abundance of these novel CD46 APA transcripts and detection of the encoded proteins in human tissues.
A Promoter Polymorphism in the CD46 Complement Regulatory Protein Gene Is Associated with Acute Renal Allograft Rejection
2016, Transplantation ProceedingsCitation Excerpt :Protection against host cell damage is regulated by complement regulatory proteins such as CD 46 and CD59 [9–11]. The CD46 gene is found on chromosome 1q32 with other genes encoding structural components of the complement system [6]. CD46 molecule (complement regulatory protein) has been known as a human cell surface receptor and plays an important role in complement and T-cell regulation for organ transplantation [11].
Using mutagenesis and structural biology to map the binding site for the plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor
2014, Journal of Biological ChemistryCitation Excerpt :The three-dimensional solution structure of CR1 1–3 was solved using a combination of NMR and SAXS, thereby allowing visualization of the spatial positions of the mutated residues (Figs. 10 and 11). As expected from a previous study of CR1 15–17 (74% sequence identity with CR1 1–3) (24, 33), all three CCPs adopt a beta-sandwich-type fold and have an ovoid appearance. Two disulfide bridges within each CCP form the boundaries of a hydrophobic core containing conserved lipophilic side chains, whereas loops and turns contain conserved glycine and proline residues.
CD46: The 'multitasker' of complement proteins
2013, International Journal of Biochemistry and Cell BiologyCitation Excerpt :CD46 is expressed on all nucleated cells, thus only erythrocytes lack CD46 expression (Andrews et al., 1985). The gene is located in the so-called ‘regulators of complement activity’ (RCA) gene cluster on chromosome 1 (1q32.2) (Hourcade et al., 1992). CD46 is commonly expressed in four distinct isoforms that arise from alternative mRNA splicing of the transcript of a single gene.
Complement inhibitor C4b-binding protein - Friend or foe in the innate immune system?
2004, Molecular Immunology
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Portions of this work have been described in abstract form Hourcade et al., 1989a, Hourcade et al., 1990a.