The interleukin-4 receptor gene (IL4R) maps to 16p11.2–16p12.1 in human and to the distal region of mouse chromosome 7
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Polymorphisms of interleukin 4 and interleukin 4 receptor genes and bronchial asthma risk among Egyptian children
2021, Clinical BiochemistryCitation Excerpt :When the IL4 binds to IL4R, the signal transducer and activator of transcription 6 (STAT6) is activated with subsequent higher expression of IL4 sensitive genes [18]. The IL4R α-subunit is encoded by the IL4R gene, mapped on the chromosome 16p12.1 (OMIM#: 147781) [19]. Several SNPs have been identified in the IL4R coding region.
Polymorphisms in the interleukin 4, interleukin 4 receptor and interleukin 13 genes and allergic phenotype: A case control study
2016, Advances in Medical SciencesCitation Excerpt :Two subunits compose the IL4 receptor (IL4R): α chain (IL4Rα), which is also present in IL13R, and γ chain, shared among other cytokine receptors [8]. IL4Rα chain gene is located on chromosome 16p [9]. Previous studies have shown that SNPs in the IL4 promoter may influence the response of mast cells to IgE-mediated signaling [10].
Association of IL-4 receptor gene polymorphisms with high density lipoprotein cholesterol
2012, CytokineCitation Excerpt :The effects of IL-4 on Th1/Th2 balance and on other immune phenotypes are mediated by binding to the IL-4 receptor (IL-4R) [13]. The heterodimeric IL-4R protein consists of a 140 kDa high-affinity α subunit (IL-4Rα) encoded by the IL-4R locus (MIM 147781) on chromosome 16p11.2–12.1 [14,15], and a common γ chain shared by several interleukin receptors [16]. By binding to IL-4R, IL-4 regulates various cellular responses, including proliferation and survival of lymphocytes, immunoglobulin isotype switching to IgE, Th2 lineage commitment of CD4+ T cells and expression of class II major histocompatibility complex and FcεRII (CD23) [17].
The genetic impact of the Q551R interleukin-4 receptor alpha polymorphism for aggressive or chronic periodontitis and the occurrence of periodontopathic bacteria
2011, Archives of Oral BiologyCitation Excerpt :The signal ways resulted from IL-4R are responsible for several cell reactions such as differentiation, proliferation and inhibition of apoptosis. The gene which encoded for the IL-4 receptor α-chain (IL-4RA) has been localized to the short arm of chromosome 16 (16p12.1).28 Variations in the IL-4RA gene have been associated with different human disorders, in particular diseases where a deregulation of the immune system or an autoimmune pathogenesis is postulated.
Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae
2021, International Journal of Obesity