Regular articlecDNA cloning of the type 1 neurofibromatosis gene: Complete sequence of the NF1 gene product
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NRas activity is regulated by dynamic interactions with nanoscale signaling clusters at the plasma membrane
2022, iScienceCitation Excerpt :We next studied whether this nanoscale organization and peripheral enrichment could occur for additional NRas-related signaling proteins at the PM. NF1 is a relatively large protein (2818 amino acids) that acts as an important negative regulator of Ras proteins (Marchuk et al., 1991), namely a RAS GAP. We visualized PAGFP-NF1 and PAmCherry-NRas in fixed cells by two-color PALM.
Phenotypic expression of a spectrum of Neurofibromatosis Type 1 (NF1) mutations identified through NGS and MLPA
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