Elsevier

Toxicology Letters

Volume 29, Issue 1, December 1985, Pages 59-63
Toxicology Letters

Cardiovascular teratogenicity of ephedrine in chick embryos

https://doi.org/10.1016/0378-4274(85)90200-0Get rights and content

Abstract

The cardiovascular teratogenicity and embryotoxicity of ephedrine was studied in chick embryos treated after 2.5–6 days of incubation (Hamburger-Hamilton developmental stages 17–28). The embryos were examined on day 14. Cardiovascular malformations were observed in 29% (29/101) of treated embryos. Complicated anomalies, such as double-outlet right ventricle (DORV), truncus arteriosus communis (TAC) or overriding aorta with ventricular septal defect (VSD) were seen frequently in embryos exposed to the agent on day 3 of incubation. Malformations were induced by ephedrine at a dose as low as 1 μmol/egg.

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Present address: Department of Pathology, Tokyo Women's Medical College, 10 Kawada-cho, Shinjuku-ku, Tokyo 162, Japan.

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