Elsevier

Gene

Volume 73, Issue 1, 15 December 1988, Pages 237-244
Gene

CLUSTAL: a package for performing multiple sequence alignment on a microcomputer

https://doi.org/10.1016/0378-1119(88)90330-7Get rights and content

Abstract

An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described. The method is based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores, obtained using a fast pairwise alignment algorithm. Then the multiple alignment is achieved from a series of pairwise alignments of clusters of sequences, following the order of branching in the tree. The method is sufficiently fast and economical with memory to be easily implemented on a microcomputer, and yet the results obtained are comparable to those from packages requiring mainframe computer facilities.

References (18)

There are more references available in the full text version of this article.

Cited by (3025)

View all citing articles on Scopus
View full text