Trends in Genetics
Volume 9, Issue 9, September 1993, Pages 317-321
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From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

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Abstract

Classical cadherins are complexed via their cytoplasmic domains with α-, β- and γ-catenin. This complex formation links cadherins to the actin filament network and to other transmembrane and cytoplasmic proteins. α-Catenin is homologous to vinculin, and β-catenin to the product of the Drosophila gene armadillo, while γ-catenin seems to be identical to plakoglobin. Catenins are part of a higher order protein structure that is of crucial importance for the adhesive function of cadherins. A working model of the construction and regulation of this multiprotein interaction is proposed.

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