Drug metabolism in pregnancy, infancy and childhood

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References (100)

  • E. Perucca

    Clinical implications of microsomal enzyme induction by antiepileptic drugs

    Clin. Pharmac. Ther.

    (1978)
  • E. Perucca et al.

    Antiepileptic drugs, pregnancy and the newborn

  • P.L. Sutton et al.

    The pharmacokinetics of theophylline in pregnancy

    J. Allergy Clin. Immunol.

    (1978)
  • E. Ackermann et al.

    The liver microsomal monooxygenase system in the human fetus: distribution in different centrifugal fractions

    Clin. Pharmac. Ther.

    (1972)
  • A. Aldridge et al.

    The disposition of caffeine during and after pregnancy

    Semin. Perinatol.

    (1981)
  • P.J. Ambrose

    Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate

    Clin. Pharmacokin.

    (1984)
  • J.V. Aranda et al.

    Pharmacokinetic aspects of theophylline in premature newborn

    New Engl. J. Med.

    (1976)
  • J.V. Aranda et al.

    Metabolism of theophylline to caffeine to human fetal liver

    Science

    (1979)
  • A.H. Bardy et al.

    Apparent plasma clearances of phenytoin, phenobarbitone, primidone and carbamazepine during pegnancy. Results of the prospective Helsinki study

  • D. Battino et al.

    Ethosuximide plasma concentrations: Influence of age and associated concomitant therapy

    Clin. Pharmacokin.

    (1982)
  • D. Battino et al.

    Changes in primidone/phenobarbitone ratio during pregnancy and the puerperium

    Clin. Pharmacokin.

    (1984)
  • D. Battino et al.

    Plasma concentrations of carbamazepine and carbamaxepine 10,11 epoxide during pregnancy and after delivery

    Clin. Pharmacokin.

    (1985)
  • M. Bonati et al.

    Theophylliline metabolism during the first month of life and development

    Ped. Res.

    (1981)
  • J.L. Brazier et al.

    Conversion of theophylline to caffeine by human fetus

    Semin. Perinatol.

    (1981)
  • B.L. Carter et al.

    Theophylline clearance during pregnancy

    Obstet. Gynecol.

    (1986)
  • S.S. Chen et al.

    Serum protein binding and free concentrations of phenytoin and phenobarbitone in pregnancy

    Brit. J. Clin. Pharmac.

    (1982)
  • A.W. Chow et al.

    Pharmacokinetics and safety of antimicrobial agents during pregnancy

    Rev. Infect. Dis.

    (1985)
  • D.R. Cook et al.

    Pharmacokinetics of antimicrobial agents during pregnancy

    Rev. Infect. Dis.

    (1976)
  • A.J. Cummings

    A surey of pharmacokinetic data from pregnant women

    Clin. Pharmacokin.

    (1983)
  • M. Dam et al.

    Antiepileptic drugs: metabolism in pregnancy

    Clin. Pharmacokin.

    (1979)
  • M. Davis et al.

    Induction of hepatic enzymes during normal pregnancy

    J. Obstetr. Gynecol.

    (1973)
  • M.E. Dean et al.

    Hepatic microsomal metabolism of drugs during pregnancy in the rat

    Drug Metab. Disp.

    (1975)
  • B.H. Dvorchik

    Drug disposition during pregnancy

    Biol. Res. Pregn.

    (1982)
  • G.J. Dutton

    Developmental aspects of drug conjugation, with special reference to glucuronidation

    Annu. Rev. Pharmac. Toxicol.

    (1978)
  • D.J. Ecobichon et al.

    Perinatal development of human blood esterases

    Clin. Pharmac. Ther.

    (1973)
  • W.E. Evans et al.

    Pharmacokinetics of anticancer drugs in children

    Drug Metab. Rev.

    (1983)
  • G. Feuer

    Action of pregnancy and various progesterones on hepatic microsomal activities

    Drug Metab. Rev.

    (1979)
  • E.G. Fichter et al.

    Sulfonamide administration in newborn and premature infants

    Am. J. Dis. Child.

    (1955)
  • J.A.H. Forrest et al.

    Clinical pharmacokinetics of paracetamol

    Clin. Pharmacokin.

    (1982)
  • M.C. Frederiksen et al.

    Theophylline pharmacokinetics in pregnancy

    Clin. Pharmac. Ther.

    (1986)
  • A.G. Frantz et al.

    6-Beta-hydroxycortisol: high levels in human urine in pregnancy and toxaemia

  • J.T. Gilman et al.

    Factors influencing theophylline disposition in 179 newborns

    Ther. Durg Monit.

    (1986)
  • T.H. Grasela et al.

    Steady-state pharmacokinetics of phenytoin from routinely collected patient data

    Clin. Pharmacokin.

    (1983)
  • L. Helleberg

    Clinical pharmacokinetics of indomethacin

    Clin. Pharmacokin.

    (1981)
  • D.M. Hilligoss et al.

    Factors affecting theophylline pharmacokinetics in premature infants with apnea

    Dev. Pharmac. Ther.

    (1980)
  • S. Hogstedt et al.

    Pregnancy-induced increase in metoprolol metabolism

    Clin. Pharmac. Ther.

    (1985)
  • M.R. Holdiness

    Clinical pharmacokinetics of the antituberculosis drugs

    Clin. Pharmacokin.

    (1984)
  • M.R. Juchau et al.

    Drug metabolism by human fetus

    Clin. Pharmacokin.

    (1980)
  • J.D. Khandekar et al.

    Effects of steroids upon the liver ultrastructure

    Rev. Can. Biol.

    (1973)
  • H. Kitigawa et al.

    Disappearance of sex difference in rat liver drug metabolism in old age

    Biochem. Pharmac.

    (1985)
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