Drug metabolism in pregnancy, infancy and childhood
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Variation in the biological half-life of methylmercury in humans: Methods, measurements and meaning
2019, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :Perhaps most relevant to explore further is the influence of the physiological state of pregnancy on MeHg metabolism and elimination. Whereas pregnancy results in faster elimination for many xenobiotics [50,51], comparable effects on MeHg remain to be explored. Nonetheless, evidence from studies on women and men in the Iraq MeHg poisoning cases suggest that the state of pregnancy, and lactation, similarly result in faster MeHg elimination [22,23,40].
Chapter 15 Seizures in Pregnancy. Diagnosis and Management
2008, International Review of NeurobiologyCitation Excerpt :As seizures are more frequent and problematic during labor, potential causes such as dehydration, sleep deprivation, and analgesics which decrease seizure threshold (such as meperidine) should be avoided. Knowledge of the pharmacokinetics of the different AEDs during pregnancy is necessary to appropriately anticipate and implement necessary medication changes (Perucca, 1987). A major factor is decreased binding to plasma proteins, which causes lower total plasma levels, but generally free (unbound) and active drug concentrations remain stable.
Management Principles of Overdose in Pregnancy
2007, Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose, Fourth EditionAre there sex and gender differences in acute exposure to chemicals in the same setting?
2006, Environmental ResearchConcerns regarding lamotrigine and breast-feeding
2004, Epilepsy and BehaviorPrenatal expression of N-acetyltransferases in C57Bl/6 mice
2003, Chemico-Biological InteractionsCitation Excerpt :Therefore, it is possible that variation in fetal expression may play a role in developmental toxicity. Enzymes involved in the activation of aromatic amines are present before birth, although these activities are often lower than those of adults [26–30]. In mice, qualitative studies show that NAT1 and NAT2 are expressed during development.