ORIGINAL ARTICLESLinkage of type 2 diabetes to the glucokinase gene
References (31)
- et al.
A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p
Genomics
(1992) - et al.
An alternate promoter in the glucokinase gene is active in the pancreatic β-cell
J Biol Chem
(1989) - et al.
Diabetes in identical twins
Diabetologia
(1981) - et al.
Concordance in type 2 (non-insulin dependent) diabetes mellitus in male twins
Diabetologia
(1987) WHO Tech Rep Ser no 727
(1985)- et al.
NIDDM without affected parents-implications for linkage analysis with genetic markers
Diabetes
(1991) - et al.
Type 2 (non-insulin-dependent) diabetes mellitus. New genetics for old nightmares
Diabetologia
(1988) - et al.
A difference between the inheritance of classical juvenile-onset and maturity-onset type diabetes of young people
Diabetes
(1975) - et al.
Maturity-onset diabetes of the young is not linked to the insulin gene
Br Med J
(1983) - et al.
Insulin gene analysis in a family with maturity-onset diabetes of the young
Diabetes
(1985)
Linkage analysis of the human insulin receptor gene in type 2 (non-insulin-dependent) diabetic families and a family with maturity onset diabetes of the young
Diabetologia
(1988)
Linkage analysis of the human insulin receptor gene and maturity-onset diabetes of the young
Diabetologia
(1987)
Analysis of the pro-opiomelancortin gene in non-insulin dependent diabetic families
Diabetes Res
(1989)
Linkage studies of maturity-onset-diabetes of the young-RW pedigree
Diabetologia
(1988)
Cited by (347)
Franz Matschinsky (1931–2022): Glucokinase characterized as the glucose sensor of pancreatic ß cells
2024, Medecine des Maladies MetaboliquesIdentification of pathogenic GCK variants in patients with common type 2 diabetes can lead to discontinuation of pharmacological treatment
2023, Molecular Genetics and Metabolism ReportsGlucokinase activity in diabetes: too much of a good thing?
2023, Trends in Endocrinology and MetabolismMaturity onset diabetes of the young type 2 (MODY2): Insight from an extended family
2021, Diabetes Research and Clinical PracticeCitation Excerpt :Mutations in GCK (MIM #138079) present with either hyperglycemia or hypoglycemia [13,15,19]. GCK mutations as the cause for MODY2 were first reported in 1992 [20-22], and over 937 different mutations have been described since then (HGMD® Professional 2020.1). Patients with MODY2 have a higher set point for glucose homeostasis and an elevated threshold for glucose-stimulating insulin secretion, presenting with mild asymptomatic stable fasting hyperglycemia (99–150 mg/dL) [10,23-25] and mildly elevated HbA1c within 5.6–7.6% (38–60 mmol/mol) [23].
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