Short note
The structural gene for the M1 subunit of ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse☆

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Abstract

The genes for the M1 subunit of the enzyme ribonucleotide reductase have been mapped in the human and the murine species by use of two independently derived mouse cDNA clones. Southern blot analysis of rodent X human somatic cell hybrid DNAs confirmed the assignment of RRM1 to the short arm of human chromosome 11. In situ hybridization to human metaphase chromosomes revealed a peak of silver grains over the distal third of band 11p15, a region corresponding to subbands p15.4 → p15.5. The mouse Rrm1 locus was assigned to chromosome 7, where it forms part of a conserved syntenic group of at least seven other genes assigned to human chromosome band 11p15.

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    ☆

    This work was supported by NIH Research Grant GM26105 to U.F.

    1

    Present address: Membrane Biology Group, University of Toronto, Toronto, Ontario, Canada M5S-1A8.

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    Copyright © 1988 Published by Elsevier Inc.