Elsevier

Clinica Chimica Acta

Volume 13, Issue 2, February 1966, Pages 207-211
Clinica Chimica Acta

Serum bile acid levels in pregnancy with pruritus (bii.e acids and steroids 158)

https://doi.org/10.1016/0009-8981(66)90294-4Get rights and content

Abstract

The serum bile acid levels in 22 healthy pregnant women have been studied with gas-liquid chromatography. The mean concentration of total bile acids was 0.087 mg% (not corrected for 15–40% loss of bile acids in the purification of the scrum extracts). The mean ratios between deoxycholic, chenodeoxycholic and cholic acids were 0.9:1.0:1.0 and only conjugated bile acids could be found.

In six cases with pruritus in the last trimester, the mean concentration of total serum bile acids was 2.48 mg%. The mean ratios between deoxycholic, chenodeoxycholic and cholic acids were 0.1:1.0:4.5. Except for traces of free bile acids in one subject, all bile acids were conjugated. Significant amounts of bile acids other than those mentioned were not found.

References (18)

  • B.B. Fast et al.

    Am. J. Obstet. Gynecol.

    (1964)
  • A. Svanborg et al.

    Am. J. Med.

    (1959)
  • H.E. Sheehan

    Am. J. Obstet. Gynecol.

    (1961)
  • T.B. Van Itallie et al.

    Med. Clin. N. Am.

    (1963)
  • D. Sandberg et al.

    J. Lipid. Res.

    (1965)
  • J. Sjövall

    Clin. Chim. Acta

    (1960)
  • E.C. Osborn et al.

    Lancet

    (1959)
  • H. Eppinger

    Die Leberkrankheiten

    (1937)
  • D.F. Brown et al.

    Arch. Internal Med.

    (1963)
There are more references available in the full text version of this article.

Cited by (85)

  • Bile acids and gestation

    2017, Molecular Aspects of Medicine
    Citation Excerpt :

    The majority of studies investigating bile acids during pregnancy show a progressive rise in serum bile acids with advancing gestation, with primary bile acids showing the highest increase. However, there is some disagreement over whether CA or CDCA is predominant in serum of pregnant women, with some studies reporting higher levels of CA (Carter, 1991; Fulton et al., 1983; Laatikainen and Hesso, 1975; Laatikainen et al., 1978; Lunzer et al., 1986; Sjovall and Sjovall, 1966) and others showing higher levels of CDCA (Heikkinen, 1983; Heikkinen et al., 1981). This inconsistency could arise from different measurement techniques or time-point of measurement in pregnancy.

  • Nuclear receptors, bile acids and cholesterol homeostasis series - Bile acids and pregnancy

    2013, Molecular and Cellular Endocrinology
    Citation Excerpt :

    Serum levels of reproductive hormones and/or their synthetic counterparts have been shown to be associated with clinical and biochemical features of ICP and to precipitate aberrant hepatobiliary processes in experimental models. Indeed, there are several reports showing that levels of serum and urinary mono- and disulphated progesterone metabolites are supraphysiologically raised in women with ICP (Laatikainen and Karjalainen, 1973; Meng et al., 1997a; Meng et al., 1997b; Meng et al., 1997c; Reyes and Sjovall, 2000; Sjovall and Sjovall, 1970; Sjovall and Sjovall, 1966). Furthermore, sulphated progesterone metabolite levels consistent with concentrations reported to be found in ICP can competitively inhibit Na+-dependent bile acid uptake into human hepatocytes in an NTCP-dependent manner (Abu-Hayyeh et al., 2010) and reduce BSEP-mediated efflux of bile acids (Vallejo et al., 2006).

  • Cholestasis of pregnancy

    2010, Obstetrics and Gynecology Clinics of North America
    Citation Excerpt :

    That said, in normal pregnancies the ratio of CA/CDCA is approximately less than 1.5.34,35 Conversely, the ratio between CA/CDCA in pregnant patients with ICP appears to be more than 1.5:1.33–35 The use of the bile acid ratio to diagnose ICP was recently evaluated, and it was found that the CA/CDCA ratio added little to the diagnosis of ICP and that the total bile acid concentration and transaminase levels were more useful.36

  • Pregnancy and liver disease

    2003, Gastroenterology Clinics of North America
  • Simultaneous determination of free and conjugated bile acids in serum by cyclodextrin-modified micellar electrokinetic chromatography

    2003, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
View all citing articles on Scopus
View full text