Serum bile acid levels in pregnancy with pruritus (bii.e acids and steroids 158)
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Cited by (85)
Bile acids and gestation
2017, Molecular Aspects of MedicineCitation Excerpt :The majority of studies investigating bile acids during pregnancy show a progressive rise in serum bile acids with advancing gestation, with primary bile acids showing the highest increase. However, there is some disagreement over whether CA or CDCA is predominant in serum of pregnant women, with some studies reporting higher levels of CA (Carter, 1991; Fulton et al., 1983; Laatikainen and Hesso, 1975; Laatikainen et al., 1978; Lunzer et al., 1986; Sjovall and Sjovall, 1966) and others showing higher levels of CDCA (Heikkinen, 1983; Heikkinen et al., 1981). This inconsistency could arise from different measurement techniques or time-point of measurement in pregnancy.
Nuclear receptors, bile acids and cholesterol homeostasis series - Bile acids and pregnancy
2013, Molecular and Cellular EndocrinologyCitation Excerpt :Serum levels of reproductive hormones and/or their synthetic counterparts have been shown to be associated with clinical and biochemical features of ICP and to precipitate aberrant hepatobiliary processes in experimental models. Indeed, there are several reports showing that levels of serum and urinary mono- and disulphated progesterone metabolites are supraphysiologically raised in women with ICP (Laatikainen and Karjalainen, 1973; Meng et al., 1997a; Meng et al., 1997b; Meng et al., 1997c; Reyes and Sjovall, 2000; Sjovall and Sjovall, 1970; Sjovall and Sjovall, 1966). Furthermore, sulphated progesterone metabolite levels consistent with concentrations reported to be found in ICP can competitively inhibit Na+-dependent bile acid uptake into human hepatocytes in an NTCP-dependent manner (Abu-Hayyeh et al., 2010) and reduce BSEP-mediated efflux of bile acids (Vallejo et al., 2006).
Cholestasis of pregnancy
2010, Obstetrics and Gynecology Clinics of North AmericaCitation Excerpt :That said, in normal pregnancies the ratio of CA/CDCA is approximately less than 1.5.34,35 Conversely, the ratio between CA/CDCA in pregnant patients with ICP appears to be more than 1.5:1.33–35 The use of the bile acid ratio to diagnose ICP was recently evaluated, and it was found that the CA/CDCA ratio added little to the diagnosis of ICP and that the total bile acid concentration and transaminase levels were more useful.36
Dexamethasone and ursodeoxycholic acid protect against the arrhythmogenic effect of taurocholate in an in vitro study of rat cardiomyocytes
2003, BJOG: An International Journal of Obstetrics and GynaecologyPregnancy and liver disease
2003, Gastroenterology Clinics of North AmericaSimultaneous determination of free and conjugated bile acids in serum by cyclodextrin-modified micellar electrokinetic chromatography
2003, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences