Changes in extracellular matrix macromolecules in human gingiva after treatment with drugs inducing gingival overgrowth
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2017, American Journal of Human GeneticsCitation Excerpt :Additionally, REST has different roles in several cellular mechanisms, such as oncogenic and tumor-suppressor functions, hematopoietic, cardiac and osteoblast differentiation, and effects on chromatin-modifying enzymes.17–21 The pathophysiologic mechanisms underlying HGF remain enigmatic; however, excessive accumulation of extracellular matrix components, particularly collagen type I, seem to contribute to the clinical-pathologic manifestations.22–24 In a comparative study performed on normal gingiva and HGF fibroblasts, Martelli-Junior et al. showed that the expression and production of type I collagen is significantly higher in fibroblasts from HGF than from normal gingiva.24
Increased expression of collagen prolyl 4-hydroxylases in Chinese patients with hereditary gingival fibromatosis
2007, Archives of Oral BiologyCitation Excerpt :Interstitial collagen accumulation is the main feature of HGF. Our quantitative analysis of fibroblasts showed higher collagen production in HGF than in CG, which is in agreement with the results of previous studies on gingival fibromatosis.1,17 Collagen homeostasis is not only determined by the synthesis of procollagen chains themselves, but also by the expression and activity of modifying and degrading enzymes like P4Hs and MMPs.
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