Family history as an independent risk factor for incident coronary artery disease in a high-risk cohort in Utah

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Abstract

To test the independence of family history of coronary artery disease (CAD) as a risk factor for the development of new clinical CAD, data collected at 2 clinic visits on 1,196 men and women, ages >20 years, were analyzed using Cox proportional hazard method. During a mean follow-up of 2.5 years, 16 new CAD cases were observed. After adjustment for age, sex, total cholesterol, high density lipoprotein cholesterol, hypertension, diabetes, cigarette smoking and body mass index, family history remained a highly significant predictor of future CAD (p = 0.0017). Only age was a more significant covariate (p = 0.0001) than family history. Sex (p = 0.0074) and serum total cholesterol (p = 0.015) also contributed significantly to CAD incidence while high density lipoprotein cholesterol, hypertension, diabetes, body mass index and several interaction terms did not improve the prediction in this population. These results provide evidence for the existence of other heritable risk factors which appear to contribute strongly to the occurrence of early CAD in many high-risk families.

References (35)

  • RR Williams et al.

    Utah pedigree studies: design and preliminary data for premature male CHD deaths

  • RM Conroy et al.

    Is family history of coronary disease an independent risk factor?

    Br Heart J

    (1985)
  • JJ Nora et al.

    Genetic-epidemiologic study, of early-onset ischemic heart disease

    Circulation

    (1980)
  • Y Friedlander et al.

    Family history of myocardial infarction as an independent risk factor for coronary heart disease

    Br Heart J

    (1985)
  • JH Chesebro et al.

    Strong family history and cigarette smoking as risk factors of coronary artery disease in young adults

    Br Heart J

    (1982)
  • K Berg

    Genetics of coronary heart disease

  • RI Sholtz et al.

    The relationship of reported parental history to the incidence of coronary heart disease in the Western Collaborative Group Study

    Am J Epidemiol

    (1975)
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    This study was supported by research grant HL 21088-10 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland.

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