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Significant association between Nijmegen breakage syndrome 1 657del5 polymorphism and breast cancer risk

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Tumor Biology

Abstract

Many studies were published to evaluate the association between Nijmegen breakage syndrome 1 (NBS1) 657del5 polymorphism and breast cancer risk, but the results remained inconsistent. To derive a more precise estimation on the possible association, we performed a meta-analysis of previous published studies. Case–control studies on the association between NBS1 657del5 polymorphisms and breast cancer risk were included into this meta-analysis. We used the odds ratio (OR) with 95 % confidence interval (95 % CI) to assess the strength of the association. Ten studies with a total of 25,365 subjects were identified and included into this meta-analysis. Meta-analysis of those ten studies showed that there was a significant association between NBS1 657del5 polymorphisms and breast cancer risk (pooled OR = 2.66, 95 % CI 1.82–3.90, P < 0.001). The cumulative meta-analyses showed a trend of a more significant association between NBS1 657del5 polymorphisms and breast cancer risk as data accumulated by publication year. Thus, our meta-analysis suggests that there was a significant association between NBS1 657del5 polymorphisms and breast cancer risk, and NBS1 657del5 polymorphism results in an increased risk of breast cancer.

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None of the authors have any conflict of interests to declare.

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Authors and Affiliations

  1. Department of General Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China

    Guofeng Zhang, Zhongyan Liu & Weiwei Wei

  2. Department of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China

    Yu Zeng

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  1. Guofeng Zhang
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  2. Yu Zeng
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  3. Zhongyan Liu
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  4. Weiwei Wei
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Correspondence to Guofeng Zhang.

Additional information

Guofeng Zhang and Yu Zeng contributed equally to this work.

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Zhang, G., Zeng, Y., Liu, Z. et al. Significant association between Nijmegen breakage syndrome 1 657del5 polymorphism and breast cancer risk. Tumor Biol. 34, 2753–2757 (2013). https://doi.org/10.1007/s13277-013-0830-z

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  • DOI: https://doi.org/10.1007/s13277-013-0830-z

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