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Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention

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  • Molecular and Cellular Biology of Cancer
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Abstract

Gastric cancer is the major cause of cancer-related deaths worldwide. The majority of them are classified as sporadic, whereas the remaining 10% exhibit familial clustering. Hereditary diffuse gastric cancer (HDGC) syndrome is the most important condition that leads to hereditary gastric cancer. However, other hereditary cancer syndromes, such as hereditary non-polyposis colorectal cancer, familial adenomatous polyposis, Peutz-Jeghers syndrome, Li-Fraumeni syndrome and hereditary breast and ovarian cancer, entail a higher risk compared to the general population for developing this kind of neoplasia. In this review, we describe briefly the most important aspects related to clinical features, molecular biology and strategies for prevention in hereditary gastric associated to different cancer syndromes.

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Authors and Affiliations

  1. Medical Oncology Department, Infanta Sofía University Hospital, San Sebastián de los Reyes, Madrid, Spain

    María Sereno, Cristina Aguayo, César Gómez-Raposo, Francisco Zambrana, Miriam Gómez-López & Enrique Casado

  2. Medical Oncology Department, Ramón y Cajal University Hospital, Madrid, Spain

    Carmen Guillén Ponce

  3. Urb. Las Azaleas, Fresno Norte, C/ Pico de la Miel 13, chalet 46, ES-28708, San Sebastián de los Reyes, Madrid, Spain

    María Sereno

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  1. María Sereno
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  2. Cristina Aguayo
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  3. Carmen Guillén Ponce
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Correspondence to María Sereno.

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Sereno, M., Aguayo, C., Ponce, C.G. et al. Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention. Clin Transl Oncol 13, 599–610 (2011). https://doi.org/10.1007/s12094-011-0705-y

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  • DOI: https://doi.org/10.1007/s12094-011-0705-y

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