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Monoallelic BAFFR P21R/H159Y Mutations and Familiar Primary Antibody Deficiencies

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References

  1. Durandy A, Kracker S, Fischer A. Primary antibody deficiencies. Nat Rev Immunol. 2013;13(7):519–33.

    Article  PubMed  CAS  Google Scholar 

  2. Warnatz K, Salzer U, Rizzi M, Fischer B, Gutenberger S, Böhm J, Kienzler AK, Pan-Hammarström Q, Hammarström L, Rakhmanov M, Schlesier M, Grimbacher B, Peter HH, Eibel H. B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans. Proc Natl Acad Sci U S A. 2009;106(33):13945–50.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  3. Losi CG, Silini A, Fiorini C, Soresina A, Meini A, Ferrari S, Notarangelo LD, Lougaris V, Plebani A. Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency. J Clin Immunol. 2005;25(5):496–502.

    Article  PubMed  CAS  Google Scholar 

  4. Pieper K, Rizzi M, Speletas M, Smulski CR, Sic H, Kraus H, Salzer U, Fiala GJ, Schamel WW, Lougaris V, Plebani A, Hammarstrom L, Recher M, Germenis AE, Grimbacher B, Warnatz K, Rolink AG, Schneider P, Notarangelo LD, Eibel H. A common single nucleotide polymorphism impairs B- cell activating factor receptor’s multimerization, contributing to common variable immunodeficiency. J Allergy Clin Immunol. 2014;133(4):1222–5.

    Article  PubMed  CAS  Google Scholar 

  5. Germinaro M, Reynolds P, Knight V, Alam R. Association of B-cell activating receptor deficiency with the P21R polymorphism and common variable immunodeficiency. Ann Allergy Asthma Immunol. 2015;115(1):82–3.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Vassilios Lougaris.

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Funding

The research leading to these results has received funding from the European Community’s Seventh Framework Programme FP7/2007-2013 under grant agreement n° 201549 (EURO-PADnet HEALTH-F2-2008-201549) and from the Italian Ministerial Grant GR-2010-2315762 to V.L. The research leading to these results also received funding from the “Fondazione C. Golgi”, Brescia.

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The authors declare no conflict of interest.

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Lougaris, V., Baronio, M., Moratto, D. et al. Monoallelic BAFFR P21R/H159Y Mutations and Familiar Primary Antibody Deficiencies. J Clin Immunol 36, 1–3 (2016). https://doi.org/10.1007/s10875-015-0217-6

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  • DOI: https://doi.org/10.1007/s10875-015-0217-6

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