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Pregnancy after prophylactic total gastrectomy

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Abstract

Hereditary diffuse gastric cancer is an autosomal dominant inherited cancer predisposition syndrome characterized by susceptibility to diffuse gastric and lobular breast cancers. Since current screening options for diffuse gastric cancer are ineffective, prophylactic total gastrectomy (PTG) is a recommended option for unaffected germline CDH1 mutation carriers. It is unknown whether pregnancy after surgery is possible or advisable due to potential maternal nutritional deficiencies. In this report we describe the pregnancy outcomes in three CDH1 mutation positive women after PTG and in a CDH1 mutation negative woman after total gastrectomy for early gastric cancer.

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Authors and Affiliations

  1. British Columbia Cancer Agency, University of British Columbia, 600 West 10th Avenue, Rm 3427, Vancouver, BC, V5Z 4E6, Canada

    Pardeep Kaurah & David G. Huntsman

  2. Medical Research Council (MRC), Cambridge, UK

    Rebecca Fitzgerald

  3. University Department of Oncology, Addenbrookes Hospital, Cambridge, UK

    Sarah Dwerryhouse

Authors
  1. Pardeep Kaurah
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  2. Rebecca Fitzgerald
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  3. Sarah Dwerryhouse
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  4. David G. Huntsman
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Correspondence to David G. Huntsman.

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I, David G. Huntsman, the Corresponding Author of this article has the right to grant on behalf of all authors and does grant on behalf of all authors, an exclusive licence (or non exclusive for government employees) on a worldwide basis to the BMJ Publishing Group Ltd to permit this article (if accepted) to be published in the Journal of Medical Genetics (JMG) and any other BMJPGL products and sublicences such use and exploit all subsidiary rights, as set out in our licence forms (http://group.bmj.com/products/journals/instructions-for-authors/licence).

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Kaurah, P., Fitzgerald, R., Dwerryhouse, S. et al. Pregnancy after prophylactic total gastrectomy. Familial Cancer 9, 331–334 (2010). https://doi.org/10.1007/s10689-009-9316-y

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  • DOI: https://doi.org/10.1007/s10689-009-9316-y

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