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Survival of Patients with Ovarian Cancer due to a Mismatch Repair Defect

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Abstract

Purpose: Hereditary non-polyposis colorectal cancer (HNPCC, Lynch syndrome) is characterized by the development of cancer of the colorectum, endometrium and other cancers. Cancer of the ovaries (OC) has frequently been reported in HNPCC. Colorectal cancer associated with HNPCC has a better survival chance compared to sporadic colorectal cancer. It is yet unknown whether patients with OC from HNPCC families (OC–HNPCC) also have a better survival. Therefore, the aim of the study was to compare the survival between patients with OC–HNPCC and a control group. Methods: A total of 26 patients with OC were identified from the Dutch HNPCC Registry. A control group (52 cases) matched for age, stage and year of diagnosis was derived from the population-based Eindhoven Cancer Registry. Data on treatment were collected for all patients. Kaplan–Meier analysis was used to calculate the crude survival. Results: The mean age at diagnosis of OC–HNPCC was significantly lower than the age of sporadic OC (49.5 vs 60.9 years). Compared to sporadic OC, OC–HNPCC was diagnosed at an earlier stage. The survival rate was not significantly different between patients with OC–HNPCC and the controls with sporadic OC. The cumulative 5-year-survival rates were 64.2 and 58.1% respectively. Conclusion On the basis of our findings, we recommend to treat OC–HNPCC similar to sporadic OC.

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References

  1. S Greggi M Genuardi P Benedetti-Panici et al. (1990) ArticleTitleAnalysis of 138 consecutive ovarian cancer patients: incidence and characteristics of familial cases Gynecol Oncol 39 300–4 Occurrence Handle10.1016/0090-8258(90)90256-K Occurrence Handle2258075 Occurrence Handle1:STN:280:DyaK3M%2FnvVKktg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  2. RS Houlston A Collins J Slack et al. (1991) ArticleTitleGenetic epidemiology of ovarian cancer: segregation analysis Ann Hum Genet 55 IssueIDPt 4 291–9 Occurrence Handle1819229 Occurrence Handle1:STN:280:DyaK38zgtl2quw%3D%3D

    PubMed  CAS  Google Scholar 

  3. SA Narod L Madlensky L Bradley et al. (1994) ArticleTitleHereditary and familial ovarian cancer in southern Ontario Cancer 74 2341–6 Occurrence Handle7922985 Occurrence Handle1:STN:280:DyaK2M%2FgsleltA%3D%3D

    PubMed  CAS  Google Scholar 

  4. C Bewtra P Watson T Conway et al. (1992) ArticleTitleHereditary ovarian cancer: A clinicopathological study Int J Gynecol Pathol 11 180–7 Occurrence Handle1399227 Occurrence Handle1:STN:280:DyaK3s%2FhsVCltA%3D%3D Occurrence Handle10.1097/00004347-199207000-00003

    Article  PubMed  CAS  Google Scholar 

  5. HT Lynch A Chapelle ParticleDe La (2003) ArticleTitleHereditary colorectal cancer N Engl J Med 348 919–2 Occurrence Handle10.1056/NEJMra012242 Occurrence Handle12621137 Occurrence Handle1:CAS:528:DC%2BD3sXhvVOit7s%3D

    Article  PubMed  CAS  Google Scholar 

  6. P Watson HF Vasen JP Mecklin et al. (1994) ArticleTitleThe risk of endometrial cancer in hereditary nonpolyposis colorectal cancer Am J Med 96 516–20 Occurrence Handle10.1016/0002-9343(94)90091-4 Occurrence Handle8017449 Occurrence Handle1:STN:280:DyaK2c3ovVSktA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  7. P Peltomaki HF Vasen (1997) ArticleTitleMutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer Gastroenterology 113 1146–58 Occurrence Handle10.1053/gast.1997.v113.pm9322509 Occurrence Handle9322509 Occurrence Handle1:CAS:528:DyaK2sXmslOlsLg%3D

    Article  PubMed  CAS  Google Scholar 

  8. P Modrich R Lahue (1996) ArticleTitleMismatch repair in replication fidelity, genetic recombination, and cancer biology Annu Rev Biochem 65 101–3 Occurrence Handle10.1146/annurev.bi.65.070196.000533 Occurrence Handle8811176 Occurrence Handle1:CAS:528:DyaK28XktFamt7k%3D

    Article  PubMed  CAS  Google Scholar 

  9. M Aarnio R Sankila E Pukkala et al. (1999) ArticleTitleCancer risk in mutation carriers of DNA-mismatch-repair genes Int J Cancer 81 214–8 Occurrence Handle10.1002/(SICI)1097-0215(19990412)81:2<214::AID-IJC8>3.0.CO;2-L Occurrence Handle10188721 Occurrence Handle1:STN:280:DyaK1M3gt1Kjtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  10. P Watson HT Lynch (1993) ArticleTitleExtracolonic cancer in hereditary nonpolyposis colorectal cancer Cancer 71 677–85 Occurrence Handle8431847 Occurrence Handle1:STN:280:DyaK3s7mtFagsQ%3D%3D

    PubMed  CAS  Google Scholar 

  11. HF Vasen EA Sanders BG Taal et al. (1996) ArticleTitleThe risk of brain tumours in hereditary non-polyposis colorectal cancer (HNPCC) Int J Cancer 65 422–5 Occurrence Handle10.1002/(SICI)1097-0215(19960208)65:4<422::AID-IJC4>3.0.CO;2-Z Occurrence Handle8621220 Occurrence Handle1:STN:280:DyaK287osVWgug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  12. HF Vasen JT Wijnen FH Menko et al. (1996) ArticleTitleCancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis Gastroenterology 110 1020–7 Occurrence Handle10.1053/gast.1996.v110.pm8612988 Occurrence Handle8612988 Occurrence Handle1:STN:280:DyaK287otlWgtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  13. T Myrhoj ML Bisgaard I Bernstein et al. (1997) ArticleTitleHereditary non-polyposis colorectal cancer: clinical features and survival.Results from the Danish HNPCC register Scand J Gastroenterol 32 572–6 Occurrence Handle9200290 Occurrence Handle1:STN:280:DyaK2szktlOltQ%3D%3D

    PubMed  CAS  Google Scholar 

  14. R Sankila LA Aaltonen HJ Jarvinen JP Mecklin (1996) ArticleTitleBetter survival rates in patients with MLH1-associated hereditary colorectal cancer Gastroenterology 110 682–7 Occurrence Handle10.1053/gast.1996.v110.pm8608876 Occurrence Handle8608876 Occurrence Handle1:STN:280:DyaK287nslOhsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  15. P Watson KM Lin MA Rodriguez-Bigas et al. (1998) ArticleTitleColorectal carcinoma survival among hereditary nonpolyposis colorectal carcinoma family members Cancer 83 259–6 Occurrence Handle10.1002/(SICI)1097-0142(19980715)83:2<259::AID-CNCR9>3.0.CO;2-L Occurrence Handle9669808 Occurrence Handle1:STN:280:DyaK1czjt1Cksw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  16. JM Carethers DP Chauhan D Fink et al. (1999) ArticleTitleMismatch repair proficiency and in vitro response to 5-fluorouracil Gastroenterology 117 123–31 Occurrence Handle10.1016/S0016-5085(99)70558-5 Occurrence Handle10381918 Occurrence Handle1:CAS:528:DyaK1MXksFelt70%3D

    Article  PubMed  CAS  Google Scholar 

  17. A Ercoli G Ferrandina G Raspaglio et al. (1999) ArticleTitlehMSH2 and GTBP expression in advanced stage epithelial ovarian cancer Br J Cancer 80 1665–71 Occurrence Handle10.1038/sj.bjc.6690579 Occurrence Handle10408416 Occurrence Handle1:CAS:528:DyaK1MXkvFKlt7o%3D

    Article  PubMed  CAS  Google Scholar 

  18. JA Plumb G Strathdee J Sludden et al. (2000) ArticleTitleReversal of drug resistance in human tumor xenografts by 2’-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter Cancer Res 60 6039–44 Occurrence Handle11085525 Occurrence Handle1:CAS:528:DC%2BD3cXotV2lsL8%3D

    PubMed  CAS  Google Scholar 

  19. CLM Marcelis HWHM Putten Particlevan der C Tops et al. (2001) ArticleTitleChemotherapy resistant ovarian cancer in carriers of an hMSH2 mutation? Familial Cancer 1 107–9 Occurrence Handle10.1023/A:1013865323890 Occurrence Handle14574006 Occurrence Handle1:STN:280:DC%2BD3svps1SnsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  20. HF Vasen FC Hartog Jager et al. (1989) ArticleTitleScreening for hereditary non-polyposis colorectal cancer: A study of 22 kindreds in The Netherlands Am J Med 86 278–81 Occurrence Handle10.1016/0002-9343(89)90296-9 Occurrence Handle2919609 Occurrence Handle1:STN:280:DyaL1M7kvVaqsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  21. HF Vasen P Watson JP Mecklin HT Lynch (1999) ArticleTitleNew clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC Gastroenterology 116 1453–6 Occurrence Handle10.1016/S0016-5085(99)70510-X Occurrence Handle10348829 Occurrence Handle1:STN:280:DyaK1M3nvVamuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  22. DE Boks AP Trujillo AC Voogd H Morreau GG Kenter HF Vasen (2002) ArticleTitleSurvival analysis of endometrial carcinoma associated with hereditary nonpolyposis colorectal cancer Int J Cancer 102 198–200 Occurrence Handle10.1002/ijc.10667 Occurrence Handle12385019 Occurrence Handle1:CAS:528:DC%2BD38XotFSjt7s%3D

    Article  PubMed  CAS  Google Scholar 

  23. E Gras L Catasus R Arguelles et al. (2001) ArticleTitleMicrosatellite instability, MLH-1 promoter hypermethylation, and frameshift mutations at coding mononucleotide repeat microsatellites in ovarian tumors Cancer 92 2829–36 Occurrence Handle11753956 Occurrence Handle1:CAS:528:DC%2BD38Xms1Q%3D

    PubMed  CAS  Google Scholar 

  24. P Watson R Butzow HT Lynch et al. (2001) ArticleTitleThe clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer Gynecol Oncol 82 223–8 Occurrence Handle10.1006/gyno.2001.6279 Occurrence Handle11531271 Occurrence Handle1:STN:280:DC%2BD3MvovFajsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  25. M Koi A Umar DP Chauhan et al. (1994) ArticleTitleHuman chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation Cancer Res 54 4308–12 Occurrence Handle8044777 Occurrence Handle1:CAS:528:DyaK2cXltlWhsbo%3D

    PubMed  CAS  Google Scholar 

  26. M Meijers MW Wagner HS Hwang et al. (2001) ArticleTitleRole of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses Cancer Res 61 5193–201

    Google Scholar 

  27. A Umar M Koi JI Risinger et al. (1997) ArticleTitleCorrection of hypermutability, N-methyl-N′-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6 Cancer Res 57 3949–55 Occurrence Handle9307278 Occurrence Handle1:CAS:528:DyaK2sXmtFehs7c%3D

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. The Netherlands Foundation for the Detection of Hereditary Tumors, Leiden University Medical Center, Poortgebouw Zuid, 2333 AA, Leiden, The Netherlands

    Th.E.M. Crijnen & H.F.A. Vasen

  2. Eindhoven Cancer Registry, Eindhoven, The Netherlands

    M.L.G. Janssen-Heijnen

  3. Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands

    H. Gelderblom, M.A. Nooij & H.F.A. Vasen

  4. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

    J. Morreau

  5. Department of Obstetrics and Gynecology, Leiden University Medical Center, Leiden, The Netherlands

    G.G. Kenter

Authors
  1. Th.E.M. Crijnen
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  2. M.L.G. Janssen-Heijnen
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  3. H. Gelderblom
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  4. J. Morreau
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  5. M.A. Nooij
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  6. G.G. Kenter
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  7. H.F.A. Vasen
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Correspondence to H.F.A. Vasen.

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Crijnen, T., Janssen-Heijnen, M., Gelderblom, H. et al. Survival of Patients with Ovarian Cancer due to a Mismatch Repair Defect. Familial Cancer 4, 301–305 (2005). https://doi.org/10.1007/s10689-005-6573-2

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  • DOI: https://doi.org/10.1007/s10689-005-6573-2

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