Skip to main content

Advertisement

Log in

Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region

  • Original investigation
  • Published:
Human Genetics Aims and scope Submit manuscript

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder in which affected individuals develop tumors primarily in the parathyroids, anterior pituitary, endocrine pancreas, and duodenum. The locus for MEN1 is tightly linked to the marker PYGM on chromosome 11q13, and linkage analysis has previously placed the MEN1 gene within a 2-Mb interval flanked by markers D11S1883 and D11S449. Loss of heterozygosity (LOH) studies in MEN1 and sporadic tumors have helped narrow the location of the gene to a 600-kb interval between PYGM and D11S449. Eighteen new polymerase chain reaction (PCR)-based polymorphic markers were generated for the MEN1 region, with ten mapping to the PYGM-D11S449 interval. These new markers, along with 14 previously known polymorphic markers, were precisely mapped on a 2.8-Mb (D11S480–D11S913) high-density clone contig-based, physical map generated for the MEN1 region.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: 21 February 1997 / Accepted: 5 June 1997

Rights and permissions

Reprints and permissions

About this article

Cite this article

Manickam, P., Guru, S., Debelenko, L. et al. Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region. Hum Genet 101, 102–108 (1997). https://doi.org/10.1007/s004390050595

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004390050595

Keywords

Navigation