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Molecular mapping of a Yq deletion in a patient with normal stature

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Abstract

The proximal long arm of the Y chromosome probably contains a gene (GCY) involved in stature determination. Recent reports have proposed the critical region extends from interval 4B to interval 5G (or 5E). In the present study, the deletion breakpoint in a male adult patient of normal height with a 46,X,del(Yq) karyotype was defined by the use of sequence-tagged site markers. The breakpoint was found between sY78 (interval 4B) and sY79 (interval 5A). The existence of a normal stature in this patient suggests that the growth determinant is proximal to sY79, therefore probably located in interval 4B or in proximal interval 5A of the Y chromosome.

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Received: 22 March 1996

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Rousseaux-Prévost, R., Rigot, JM., Delobel, B. et al. Molecular mapping of a Yq deletion in a patient with normal stature. Hum Genet 98, 505–507 (1996). https://doi.org/10.1007/s004390050248

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  • DOI: https://doi.org/10.1007/s004390050248

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