Summary
Superoxide dismutase was administered intravenously to rats 50 min prior to intravenous administration of a diabetogenic dose of streptozotocin. A dose of 45 mg/kg streptozotocin alone produced marked glucose intolerance and a decrease in pancreatic insulin content to less than 10% of control; both of these effects were abolished by prior administration of 105 u/g of superoxide dismutase. Superoxide dismutase (105 u/g) administered 50 min before 65 mg/kg intravenous streptozotocin did not prevent the development of diabetes. The fall in pancreatic insulin content seen with streptozotocin alone was, however, partially reversed by superoxide dismutase.
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Robbins, M.J., Sharp, R.A., Slonim, A.E. et al. Protection against streptozotocin-induced diabetes by superoxide dismutase. Diabetologia 18, 55–58 (1980). https://doi.org/10.1007/BF01228303
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DOI: https://doi.org/10.1007/BF01228303