Skip to main content
Log in

Chromosome studies in 952 infertile males with a sperm count below 10 million/ml

  • Short Communications
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

A major chromosomal abnormality was observed in 10.3% of subfertile men in this study. This result is similar to a previous survey using the same criteria for selection of probands. The high frequency of chromosomal abnormalities emphasizes the importance of cytogenetic examination in subfertile men. The detection of such an abnormality should be followed by chromosome analysis in the patient's family. Prenatal diagnosis is indicated if a subfertile man with an abnormal karyotype fathers a child.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Caspersson T, Zech L, Johansson C, Modest EJ (1970) Identification of human chromosome by DNA binding fluorescing agents. Chromosoma 30:215–227

    Google Scholar 

  • Chandley AC (1979) The chromosomal basis of human infertility. Br Med Bull 35:181–186

    PubMed  Google Scholar 

  • Colombies P, Bourrouillou G, Pontonnier F (1983) Anomalies chromosomiques chez les hommes stériles. Etude chez 717 sujets. Press Med 12:773

    Google Scholar 

  • Dutrillaux B, Le Lorier G, Salat J, Rotman J (1971) Incidence des anomalies chromosomiques dans la stérilité masculine. A propos d'une étude de 40 cas. Press Med 79:1231–1234

    Google Scholar 

  • Hook EB, Hamerton JL (1977) The frequency of chromosome abnormalities detected in consecutive newborn studies. Differences between studies. Results by sex and severity of phenotypic involvements. In: Hook EB, Porter IH (eds) Population cytogenetics: studies in humans. Academic Press, London, pp 63–79

    Google Scholar 

  • Kjessler B (1972) Facteurs génétiques dans la subfertilité male humaine. In: Fécondité et stérilité du male. Acquisitions récentes. Masson, Paris, pp 205–225

    Google Scholar 

  • Koulischer L, Schoysman R (1975) Etude des chromosomes mitotiques et méiotiques chez les hommes infertiles. J Genet Hum [Suppl] 23:58–70

    PubMed  Google Scholar 

  • Luciani JM, Guichaoua MR (1985) Anomalies chromosomiques au cours des stérilités masculines. Ann Biol Clin (Paris) 43:71–74

    Google Scholar 

  • Retief AE, Van Zyl JA, Menkueld R, Fox MF, Kotze GM, Brunsnicky J (1984) Chromosome studies in 496 infertile males with a sperm count below 10 million/ml. Hum Genet 66:162–164

    Article  PubMed  Google Scholar 

  • Seabright M (1971) A rapid banding technique for human chromosomes. Lancet II:971–972

    Article  Google Scholar 

  • Zuffardi O, Tiepolo L (1982) Frequencies and types of chromosome abnormalities associated with human male infertility. In: Crosignani PG, Rubin BL (eds) Serano Clinical Cologuia on Reproduction. III. Genetic control of gamete production and function. Academic Press/Grune & Stratton, London, pp 261–273

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bourrouillou, G., Dastugue, N. & Colomies, P. Chromosome studies in 952 infertile males with a sperm count below 10 million/ml. Hum Genet 71, 366–367 (1985). https://doi.org/10.1007/BF00388466

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00388466

Keywords

Navigation