Skip to main content
Log in

Down's syndrome in Western Australia: Cytogenetics and incidence

  • Original Investigations
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

235 cases of Down's syndrome were ascertained in a 10-year study of Down's syndrome in Western Australia. Although cytogenetic studies performed on 222 subjects confirmed that 95% of cases were trisomic due to nondisjunction, 4% were trisomic due to translocation, and 1% were mosaic, the ratio of inherited/sporadic translocations differed from that usually reported. Comparison of the results with those of an earlier Australian survey of Down's syndrome demonstrated a real fall in the incidence of Down's syndrome in Australia but no significant change in maternal age-specific incidences.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Borrie, W. D.: Population and Australia: A demographic analysis and projection. (2 vols.) Canberra: Australian Government Publishing Service 1975

    Google Scholar 

  • Collmann, R. D., Stoller, A.: A survey of mongoloid births in Victoria, Australia, 1942–1957. Am. J. Public Health 52, 813–829 (1962)

    Google Scholar 

  • Edwards, J. H.: The recognition and estimation of cyclic trends. Ann. Hum. Genet. 25, 83–87 (1961)

    Google Scholar 

  • Harlap, S.: A time-series analysis of the incidence of Down's syndrome in West Jerusalem. Am. J. Epidemiol. 99, 210–217 (1974)

    Google Scholar 

  • Haynes, S. G., Gibson, J. B., Kurland, L. T.: Epidemiology of neural tube defects and Down's syndrome in Rochester, Minnesota, 1935–1971. Neurology (Minneap.) 24, 691–700 (1974)

    Google Scholar 

  • Hook, E. B.: Estimates of maternal age-specific risks of a Down's syndrome birth in women aged 34–41. Lancet 1976II, 33–34

  • Kuroki, Y., Yamamoto, Y., Matsui, I., Kurita, T.: Down syndrome and maternal age in Japan, 1950–1973. Clin. Genet. 12, 43–46 (1977)

    Google Scholar 

  • Lindsjö, A.: Down's syndrome in Sweden. An epidemiological study of a three-year material. Acta Paediatr. Scand. 63, 571–576 (1974)

    Google Scholar 

  • Mikkelsen, M.: Down's syndrome at young maternal age: cytogenetical and genealogical study of eighty-one families. Ann. Hum. Genet. 31, 51–69 (1967)

    Google Scholar 

  • Mikkelsen, M.: Down's syndrome. Current state of cytogenetic research. Hum. Genet. 12, 1–28 (1971)

    Google Scholar 

  • Mikkelsen, M., Fischer, G., Stene, J., Stene, E., Petersen, E.: Incidence study of Down's syndrome in Copenhagen, 1960–1971: with chromosome investigation. Ann. Hum. Genet. 40, 177–182 (1976)

    Google Scholar 

  • Morris, R.: Down's syndrome in New Zealand. N.Z. med. J. 73, 195–198 (1971)

    Google Scholar 

  • Paul, F.: A study of mongolism in Singapore children. J. Singapore Paediatr. Soc. 16, 70–85 (1974)

    Google Scholar 

  • Penrose, L. S.: The relative effects of paternal and maternal age in mongolism. J. Genet. 27, 219–224 (1933)

    Google Scholar 

  • Robinson, A., Goad, W. B., Puck, T. T., Harris, J. S.: Studies on chromosomal nondisjunction in man. Am. J. Hum. Genet. 21, 466–585 (1969)

    Google Scholar 

  • Rothman, K. G., Fabia, J. J.: Place and time aspects of the recurrence of Down's syndrome. Am. J. Epidemiol. 103, 560–564 (1976)

    Google Scholar 

  • Stene, J., Fischer, G., Stene, E., Mikkelsen, M., Petersen, E.: Paternal age effect in Down's syndrome. Ann. Hum. Genet. 40, 299–306 (1977)

    Google Scholar 

  • Stoller, A., Collmann, R. D.: Incidence of infective hepatitis followed by Down's syndrome nine months later. Lancet 1965II, 1221–1223

  • Uchida, I. A.: Epidemiology of mongolism: the Manitoba study. Ann. N.Y. Acad. Sci. 171, 361–369 (1970)

    Google Scholar 

  • Verma, I. C., Singh, M.: Down's syndrome in India. Lancet 1975I, 1200

  • Zeuthen, E., Nielsen, J., Nielsen, A.: Prevalence of Down's syndrome. Hereditas 75, 136–138 (1975)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mulcahy, M.T. Down's syndrome in Western Australia: Cytogenetics and incidence. Hum Genet 48, 67–72 (1979). https://doi.org/10.1007/BF00273276

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00273276

Keywords

Navigation