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Trinucleotide Repeat Protocols pp 3–17Cite as

A Brief History of Triplet Repeat Diseases

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1010))

Abstract

Instability of repetitive DNA sequences within the genome is associated with a number of human diseases. The expansion of trinucleotide repeats is recognized as a major cause of neurological and neuromuscular diseases, and progress in understanding the mutations over the last 20 years has been substantial. Here we provide a brief summary of progress with an emphasis on technical advances at different stages.

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Acknowledgments

I would like to thank Christie A. Canaria, Virginia Platt (NIH/NIA T32-AG00266), Do Yup Lee, Nelson Chan, Ella Xun, James Lim, and support from the National Institutes of Health Grants NS069177, NS40738, NS062384, and NS060115.

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Authors and Affiliations

  1. Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA

    Helen Budworth

  2. Life Sciences Division, Lawrence Berkeley National laboratory, Berkeley, CA, USA

    Cynthia T. McMurray

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  1. Helen Budworth
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  2. Cynthia T. McMurray
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Editors and Affiliations

  1. Life Sciences Division, Lawrence Berkeley National Laboratory, Cyclotron Road, MS-977 1, Berkeley, 94720, California, USA

    Yoshinori Kohwi

  2. Life Sciences Division, Lawrence Berkeley National Laboratory, Cyclotron Road, MS-83 1, Berkeley, 94720, California, USA

    Cynthia T. McMurray

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Budworth, H., McMurray, C.T. (2013). A Brief History of Triplet Repeat Diseases. In: Kohwi, Y., McMurray, C. (eds) Trinucleotide Repeat Protocols. Methods in Molecular Biology, vol 1010. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-411-1_1

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  • DOI: https://doi.org/10.1007/978-1-62703-411-1_1

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  • Publisher Name: Humana Press, Totowa, NJ

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