Regular ArticleIdentification of a Psoriasis Susceptibility Candidate Gene by Linkage Disequilibrium Mapping with a Localized Single Nucleotide Polymorphism Map
References (44)
Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C
Am. J. Hum. Genet.
(2000)Searching for psoriasis susceptibility genes in Italy: genome scan and evidence for a new locus on chromosome 1
J. Invest. Dermatol.
(1999)Genomewide scan in German families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13
Am. J. Hum. Genet.
(2000)- et al.
Creation of a yeast artificial chromosome fragmentation vector based on lysine-2
Genet. Anal. Techn. Appl.
(1992) - et al.
Transmission/disequilibrium tests for extended marker haplotypes
Am. J. Hum. Genet.
(1999) - et al.
Prediction of complete gene structures in human genomic DNA
J. Mol. Biol.
(1997) Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon
J. Biol. Chem.
(1995)Psoriasis
Lancet
(1997)- et al.
Linkage disequilibrium mapping of complex disease: fantasy or reality?
Curr. Opin. Biotechnol.
(1998) What is significant in whole-genome linkage disequilibrium studies?
Am. J. Hum. Genet.
(1997)
A 4Mb high-density single nucleotide polymorphism-based map around human APOE
Genomics
The I.M.A.G.E. consortium: an integrated molecular analysis of genomes and their expression
Genomics
Clinical Dermatology
The genetics of psoriasis: a complex disorder of the skin and immune system
Hum. Mol. Genet.
Age at onset and different types of psoriasis
Br. J. Dermatol.
Psoriasis and HLA-Cw6
Br. J. Dermatol.
HLA B13, B17, B37 and Cw6 in psoriasis vulgaris: association with age of onset
Arch. Dermatol. Res.
Novel genetic association between the corneodesmosin (MHC S) gene and susceptibility to psoriasis
Hum. Mol. Genet.
Evidence that a locus for familial psoriasis maps to 4q
Nat. Genet.
Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q
Science
Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan
Hum. Mol. Genet.
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2021, Developmental and Comparative ImmunologyCitation Excerpt :Recently, Slc12a8 gene has been described as a specific NMN transporter that is highly expressed in the mouse small intestine (Grozio et al., 2019). This gene was previously identified as a psoriasis susceptibility gene since it contains single-nucleotide polymorphisms (SNPs), which have been found to be associated with psoriasis (Hewett et al., 2002). In addition, NMN and NAD+ can be transformed into NR, which is preferentially transported into the cell; only neurons seem to be able to uptake NAD+ (Rajman et al., 2018) (Fig. 2).
Genetic and epigenetic basis of psoriasis pathogenesis
2015, Molecular ImmunologyCitation Excerpt :Another case control study by the same group identified fifteen additional rare missense variants in CARD14 and showed their effects on NF-κB activation and the transcriptome of keratinocytes (Jordan et al., 2012a). Besides, several tentative psoriasis linkage sites were found on chromosomal regions 4q34 (PSORS3) (Liu et al., 2008; Matthews et al., 1996; Nair et al., 1997), 1q21 (PSORS4) (Bhalerao and Bowcock, 1998; Capon et al., 1999a,b, 2001; Chen et al., 2009; de Cid et al., 2009; Zhang et al., 2009b), 3q21 (PSORS5) (Enlund et al., 1999b; Hewett et al., 2002; Huffmeier et al., 2005; Vasilopoulos et al., 2008), 19p13 (PSORS6) (Huffmeier et al., 2009a; Lee et al., 2000), 1p32 (PSORS7) (Capon et al., 2007; Cargill et al., 2007; Huffmeier et al., 2009b; Nair et al., 2009; Veal et al., 2001), 16q (PSORS8) (Nair et al., 1997), 4q31 (PSORS9) (Zhang et al., 2002), 18p11 (PSORS10) (Asumalahti et al., 2003), 5q31-q33 (PSORS11) (Capon et al., 2007; Cargill et al., 2007; Huffmeier et al., 2009b; Nair et al., 2009; Zhang et al., 2009b), 20q13 (PSORS12) (Capon et al., 2008; Onoufriadis et al., 2012), 6q21 (PSORS13) (Ellinghaus et al., 2010; Huffmeier et al., 2010) and regions 2q (D2S134) (Ammar et al., 2013; Trembath et al., 1997), 9q (Ammar et al., 2013; Nair et al., 2009), 12q (Ammar et al., 2013) and 13q (Ammar et al., 2013). Additionally, linkage of chromosomes 10p, 13q, 14q, 16p and 20p was also reported (Lesueur et al., 2007).
Psoriasis: Physiopathology and immunogenetics
2014, Pathologie Biologie
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Present address: MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
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Present address: Variagenics Inc., 60 Hampshire St., Cambridge, Massachusetts 02139, USA