Regular ArticleA High-Resolution Genetic, Physical, and Comparative Gene Map of the Doublefoot (Dbf) Region of Mouse Chromosome 1 and the Region of Conserved Synteny on Human Chromosome 2q35
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Chapter 13 Long-Range Gene Control and Genetic Disease
2008, Advances in GeneticsCitation Excerpt :This suggests that perhaps the role of one of the endogenous Shh regulatory elements is to act as repressor segregating the activity of Shh from Ihh (de la Fuente and Helms, 2005). Direct misregulation of Ihh itself has been implicated in the Doublefoot mutant that shows PPD and craniofacial abnormalities (Hayes et al., 2001; Yang et al., 1998). In a small but growing number of cases the observed phenotypes cannot easily be explained by hypothesizing the involvement of a single gene, but are more likely to be the result of a combination of effects on two or more genes, either neighboring genes under common control or artificially juxtaposed by a translocation.
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Present address: Department of Molecular Biology, Neuroscience Research Centre, Merck, Sharp and Dohme, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, UK
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These authors contributed equally to this work.
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To whom correspondence and reprint requests should be addressed. Fax: +44 (0) 1279 440390. E-mail: [email protected].
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Present address: MetaGen Pharmaceuticals, Ihnestrasse 63, 14195 Berlin, Germany
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Present address: Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK