Elsevier

Genomics

Volume 69, Issue 1, 1 October 2000, Pages 47-53
Genomics

Regular Article
Quantitative Trait Loci Affecting Prion Incubation Time in Mice

https://doi.org/10.1006/geno.2000.6320Get rights and content

Abstract

Although the gene encoding prion protein (PrP) is the major determinant of susceptibility to prion disease, other genes also affect prion incubation time in mice and may be involved in prion replication. Scrapie incubation time was analyzed as a quantitative trait using crosses between SJL/J and CAST/Ei mice; these mouse strains encode identical PrP molecules but have different incubation periods. Our analysis revealed loci on Chromosomes 9 and 11 that affect prion susceptibility.

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    To whom correspondence should be addressed at McLaughlin Research Institute, 1520 23rd Street South, Great Falls, MT 59405. Telephone: (406) 454-6044. Fax: (406) 454-6019. E-mail: [email protected].

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