Regular ArticleGenomic Mapping of Chromosomal Region 2p15–p21 (D2S378–D2S391): Integration of Genemap'98 within a Framework of Yeast and Bacterial Artificial Chromosomes☆
References (52)
- et al.
Structure, promoter analysis and chromosomal assignment of the human APEX gene
Biochim. Biophys. Acta
(1994) - et al.
A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region
Genomics
(1999) - et al.
Construction of a 1.5-Mb bacterial artificial chromosome contig in Xp11.23, a region of high gene content
Genomics
(1998) Cytogenetic studies in prostate cancer: Are we making progress
Cancer Genet. Cytogenet.
(1997)- et al.
From amplification to gene in thyroid cancer: A high-resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization
Am. J. Hum. Genet.
(1998) - et al.
Human/mouse homology relationships
Genomics
(1996) - et al.
Malattia leventinese: Refinement of the genetic locus and phenotypic variability in autosomal dominant macular drusen
Am. J. Opthalmol.
(1998) - et al.
Clinical relevance of chromosome abnormalities in non-small cell lung cancer
Cancer Genet. Cytogenet.
(1998) - et al.
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
Cell
(1993) - et al.
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
Cell
(1993)
Radiation hybrid mapping of chromosomal region 2p15–p16: Integration of expressed and polymorphic sequences maps at the Carney complex (CNC) and Doyne's honeycomb retinal dystrophy (DHRD) loci
Genomics
Comparison of DNA copy number changes in malignant mesothelioma, adenocarcinoma and large-cell anaplastic carcinoma of the lung
Br. J. Cancer
The complex of myxomas, spotty pigmentation, and endocrine overactivity
Medicine
A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
Nat. Genet.
A physical map of 30,000 human genes
Science
A new gene (DYX3) for dyslexia is located on chromosome 2
Am. J. Hum. Genet.
The gene responsible for autosomal dominant Doyne's honeycomb retinal dystrophy (DHRD) maps to chromosome 2p16
Hum. Mol. Genet.
A radiation hybrid map of the human genome
Hum. Mol. Genet.
High resolution ordering of YAC contigs using extended chromatin and chromosomes
Hum. Mol. Genet.
A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10
Nat. Genet.
Linkage of autosomal dominant radial drusen (malattia leventinese) to chromosome 2p16–21
Arch. Ophthalmol.
A method for simultaneous detection of fluorescent G-bands and in situ hybridization signals
Cytogenet. Cell Genet.
Refined genetic and physical positioning of the gene for Doyne honeycomb retinal dystrophy (DHRD)
Hum. Genet.
Large scale preparation of sequence-ready BAC DNA using Qiagen columns
BioTechniques
Genotyping of adrenocortical tumors: Very frequent deletions of the MEN1 locus in 11q13 and of a 1-centimorgan region in 2p16
J. Clin. Endocrinol. Metab.
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Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776
2012, Journal of Biological ChemistryCitation Excerpt :Polynucleotide phosphorylase (PNPase) is an evolutionary conserved 3′-5′ exoribonuclease that uses the phosphorolytic mechanism to degrade RNA (19–22). It maps to 2p15–2p16.1 in which genomic alterations like deletion and amplification have been implicated in human cancers, such as diffuse large B-cell lymphoma (23) and various genetic disorders (24). PNPase consists of five motifs, including two catalytic RNase PH domains separated by an α-helical domain and two RNA-binding domains, KH and S1, at the C terminus (25, 26).
PNPASE and RNA trafficking into mitochondria
2012, Biochimica et Biophysica Acta - Gene Regulatory MechanismsCitation Excerpt :The PNPT1 gene is ~ 60 kb in length, contains 28 exons, and is located at 2p16.1 (UCSC Genome Browser, Assembly GRCh37/hg19, February, 2009). This genomic region shows deletions and amplifications in human B cell lymphoma and in several genetic disorders [28,29]. Relatively little is known about the transcriptional or post-transcriptional regulation of PNPT1 expression.
PRKAR1A and the evolution of pituitary tumors
2010, Molecular and Cellular EndocrinologyHuman polynucleotide phosphorylase: location matters
2007, Trends in Cell BiologyCitation Excerpt :PNPT1 was cloned during a screen for genes up-regulated in both terminally differentiated melanoma cells and senescent progeroid fibroblasts, which are cells characterized by irreversible growth arrest [14]. The approximately 54 kb PNPT1 gene consists of 28 exons and maps to 2p15–2p16.1, a notably unstable genomic region prone to deletions and amplifications that have been implicated in human cancers, such as diffuse large B-cell lymphoma [21], and in various genetic disorders [22]. To date, however, there is no evidence linking changes in hPNPase expression or function to any specific pathological process.
Polynucleotide phosphorylase: An evolutionary conserved gene with an expanding repertoire of functions
2006, Pharmacology and TherapeuticsPresymptomatic diagnosis using a deletion of a single codon in families with hereditary non-polyposis colorectal cancer
2005, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
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This work was (in part) presented in an abstract form at the 80th Annual Meeting of the Endocrine Society, New Orleans, Louisiana June 24–27, 1998.
- 1
To whom correspondence should be addressed at Unit on Genetics and Endocrinology, DEB, NICHD, NIH, Building 10, Room 10N262, 10 Center Drive MSC1862, Bethesda, MD 20892-1862. Telephone: (301) 496-4686 or 402-1998. Fax: (301) 402-0574. E-mail: [email protected].