Regular ArticleTOM1Genes Map to Human Chromosome 22q13.1 and Mouse Chromosome 8C1 and Encode Proteins Similar to the Endosomal Proteins HGS and STAM☆
References (34)
- et al.
Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth
J. Biol. Chem.
(1997) - et al.
Human/mouse homology relationships
Genomics
(1996) Myb: A transcriptional activator linking proliferation and differentiation in hematopoietic cells
Curr. Opin. Genet. Dev.
(1992)- et al.
Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes
J. Biol. Chem.
(1997) - et al.
Chromosomal localization of the human heme oxygenase genes: Heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3
Genomics
(1994) - et al.
East, an epidermal growth factor receptor- and eps15-associated protein with src homology 3 and tyrosine-based activation motif domains
J. Biol. Chem.
(1998) - et al.
Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
Genomics
(1989) Adaptins
Trends Cell Biol.
(1992)The role of clathrin, adaptors and dynamin in endocytosis
Curr. Opin. Cell Biol.
(1994)- et al.
Membrane dynamics in endocytosis
Cell
(1996)
Increase of insulin-like growth factor (IGF)-1, IGF binding protein-2 and -4 mRNAs following cerebral contusion
Brain Res. Mol. Brain Res.
The human zinc finger protein EGR-4 acts as autoregulatory transcriptional repressor
Biochim. Biophys. Acta
Hrs-2 is an ATPase implicated in calcium-regulated secretion
Nature
Tom-1, a novel v-myb target gene expressed in amv- and e26-transformed myelomonocytic cells
EMBO J.
CDC46/MCM5, a yeast protein whose subcellular localization is cell cycle-regulated, is involved in DNA replication at autonomously replicating sequences
Proc. Natl. Acad. Sci. USA
Cloning and sequence analysis of a cDNA encoding rat preprocholecystokinin
Proc. Natl. Acad. Sci. USA
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Transcriptional activities of the sleeping beauty transposon and shielding its genetic cargo with insulators
2008, Molecular TherapyCitation Excerpt :We identified the cellular HMG2L1 protein as a cellular interactor of the SB transposase (Figure 3). HMG2L1 is an HMG-box DNA-binding domain-containing protein38 that shares structural similarity with the LEF-1, Sox-4 and SRY proteins. These proteins bind to DNA in a sequence-specific fashion through minor groove contacts, and alter DNA conformation upon binding.32
TOM1L1 is a Lyn substrate involved in FcεRI signaling in mast cells
2007, Journal of Biological ChemistryCitation Excerpt :TOM1L1 is one of the clones that we identified in the phosphorylation screen with Lyn. The gene of TOM1L1 was identified as a human paralog of the avian TOM1 (39). However, the function of this protein is still not very clear.
Endofin Recruits TOM1 to Endosomes
2004, Journal of Biological ChemistryCitation Excerpt :Endofin Interacts Specifically with TOM1 but Not TOM1-L1 or TOM1-L2—A search of the data base reveals that TOM1 is a member of a family of three closely related proteins. The sequences of the two other members, namely TOM1-like 1 (TOM1-L1) (37, 39) and TOM1-like 2 (TOM1-L2) (accession number AF467441), have been reported. Alignment of the three sequences suggests a similar structural organization for the proteins, including a putative amino-terminal VHS and a central GAT domain (Fig. 4A).
The origin recognition complex marks a replication origin in the human TOP1 gene promoter
2002, Journal of Biological ChemistryCitation Excerpt :Two of the sequences were detected at high copy numbers in independent immunoprecipitates of cross-linked chromatin. One of the sequences corresponded to a region close to the geneTOM1 on human chromosome 22q13.1 (59). The cloned sequence revealed a higher than average G+C content (51%), with consecutive CpG dinucleotides and is, therefore, related to mapped ORC binding regions at active genes.
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Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession Nos. AJ006973 (Homo sapiensmRNA for TOM1 protein); AJ006972 (Mus musculusmRNA for Tom1 protein); AC005290 (M. musculusChromosome 8 PAC Clone 411O19); AJ010069 (Human high mobility group box containing gene HMG2L1); AJ010070 (Human partial transcript encompassing THC211630-gene); and AJ010071 (HumanTOM1like gene 1, TOM1L1).
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