Regular ArticleLinkage of Asthma to Markers on Chromosome 12 in a Sample of 240 Families Using Quantitative Phenotype Scores☆
References (37)
- et al.
Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Carribean and Caucasian populations
Genomics
(1996) - et al.
Linkage map integration
Genomics
(1996) - et al.
One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes
Genomics
(1991) - et al.
Evidence for linkage of chromosome 12q15–q24.1 markers to high total serum IgE concentrations in children of the German multicenter allergy study
Genomics
(1997) - et al.
Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22–q24
Cell Growth Differ.
(1991) Statistical Estimates and Transformed Beta Variables
(1958)- et al.
Validity and repeatability of the IUATLD (1984) Bronchial Symptoms Questionnaire: An international comparison
Eur. Respir. J.
(1989) - et al.
Effects of misspecifying genetic parameters in lod score analysis
Biometrics
(1986) - Collaborative Study on the Genetics of Asthma (CGSA). (1997). A genome-wide search for asthma susceptibility loci in...
- et al.
Nonparametric tests for linkage with dependent sib pairs
Hum. Hered.
(1995)
Mapping a disease locus by allelic association
Proc. Natl. Acad. Sci. USA
Trials of the β model for complex inheritance
Proc. Natl. Acad. Sci. USA
Investigating the asthma phenotype
Clin. Exp. Allergy
Allelic association of markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness
Am. J. Respir. Crit. Care Med.
Introduction to Quantitative Genetics
The genetic basis for constructing selection indices
Genetics
An Introduction to Genetic Statistics
Parametric and nonparametric linkage analysis: A unified multipoint approach
Am. J. Hum. Genet.
Cited by (74)
The Genetics of Allergic Disease and Asthma
2016, Pediatric Allergy: Principles and Practice: Third EditionA genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom
2011, Journal of Allergy and Clinical ImmunologyThe Genetics of Allergic Disease and Asthma
2010, Pediatric Allergy: Principles and Practice Expert Consult: Second EditionChromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia
2009, Immunology LettersCitation Excerpt :We have observed a peak of a suggestive linkage at the positions of 136–140 cM for cat-specific IgE and some evidence of linkage for total IgE at the same position. The linkage of the region 12q24.3 (125–134 cM) with total IgE, asthma and wheeze, eosinophil count and airway responsiveness, was reported in Dutch [2,5] and Japanese [6], British [15], French [38] and Costa Rica Hispanic [17] population, respectively, supporting the important role of this locus in development of asthma and atopy related traits (Fig. 2). The locus at 136–140 cM linked to cat-specific IgE detected in the present study is located in a close proximity (within 9 cM) to the loci described above (Fig. 2) and confirms previous reports of atopy related loci at this site [2,5,6,15,17,38].
Asthma genetics: Pitfalls and triumphs
2005, Paediatric Respiratory ReviewsAssociation analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes
2005, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Interestingly, 1 of the 3 haplotypes showing association already in the family data was also observed to associate in the replication data (Table II). On the basis of chromosomal linkage studies and their function, STAT6 and STAT4 are positional candidates for asthma and atopy.8-12,30 GATA3 and T-BET are essential transcription factors in the differentiation of T helper lymphocytes.
- ☆
N. E. MortonD. C. RaoJ.-M. Lalouel
- 1
To whom correspondence should be addressed at Human Genetics, Level G, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK. Telephone: 01703 796535. Fax: 01703 798416. E-mail:[email protected].