Regular ArticleThree Murine Cataract Mutants (Cat2) Are Defective in Different γ-Crystallin Genes☆
References (32)
- et al.
Nucleotide sequence of the rat γ-crystallin gene region and comparison with an orthologous human region
Gene
(1989) - et al.
Mapping of six dominant cataract genes in the mouse
Genomics
(1994) A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea
Mutat. Res.
(1983)- et al.
The effect of the interval between dose applications on the observed specific-locus mutation rate in the mouse following fractionated treatments of spermatogonia with ethylnitrosourea
Mutat. Res.
(1997) - et al.
Temporal regulation of six crystallin transcripts during mouse lens development
Exp. Eye Res.
(1992) - et al.
Murine γE-crystallin is distinct from murine γ2-crystallin
Gene
(1991) - et al.
Dominant cataract and recessive specific locus mutations in offspring of X-irradiated male mice
Mutat. Res.
(1986) - et al.
Genetical and biochemical studies of a dominant cataract mutant in mice
Exp. Eye Res.
(1984) - et al.
Genomic sequences of murine γB- and γC-crystallin-encoding genes: Promoter analysis and complete evolutionary pattern of mouse, rat and human γ-crystallins
Gene
(1993) - et al.
Catalase and superoxide dismutase activities in lenses of cataractousNOP
Exp. Eye Res.
(1985)
Nop. Exp. Eye Res.
Close linkage of the dominant cataract mutations (Cat-2Idh-1Cryge
Genomics
The evolution of lenticular proteins: the β- and γ-crystallin super gene family
Prog. Biophys. Mol. Biol.
Strict co-linearity of genetic and protein folding domains in an intragenically duplicated rat lens γ-crystallin gene
J. Mol. Biol.
Towards a molecular understanding of phase separation in the lens: A comparison of the X-ray structures of two high Tcc
Exp. Eye Res.
Cited by (64)
A novel cataract-causing mutation Ile82Met of γA crystallin trends to aggregate with unfolding intermediate
2022, International Journal of Biological MacromoleculesCitation Excerpt :In this project, we identified a novel causative mutation of γA-crystallin in a three-generation Chinese family and elucidated the pathomechanisms underlying the cataract. Some mutations in γA-crystallin have been found to cause the cataract in mouse models; for example, Cryga1Neu and Crygatol mutants exhibited nuclear opacities, and CrygaSecc showed congenital nuclear cataract [30,40]. p53 regulates the expression of γA-crystallin by binding to the gene promoter and is involved in mouse lens development [41].
Silver nanoparticles affect lens rather than retina development in zebrafish embryos
2018, Ecotoxicology and Environmental SafetyCitation Excerpt :Genes associated with cataract in mammals including human have been studied for many years. It was reported that the mutation of genes encoding crystallins such as CRYAA, CRYAB, CRYBA1, CRYBB1, CRYBB2, CRYGC, CRYGD caused cataract in mouse even in humans (Klopp et al., 1998; Litt et al., 1997, 1998). This study revealed that 30 of total 45 down-regulated eye genes in AgNPs exposed embryos were crystallin genes and these 30 genes derived from all the α-crystallin, β-crystallin, and γ- crystallin families.
Genetics of crystallins: Cataract and beyond
2009, Experimental Eye ResearchCataracts in transgenic mice caused by a human papillomavirus type 18 E7 oncogene driven by KRT1-14
2008, Experimental and Molecular PathologyMouse Models of the Cornea and Lens: Understanding Ocular Disease
2008, Animal Models in Eye Research
- ☆
Sequence data from this article have been deposited with the EMBL Data Library under Accession Nos. AJ224342 for mouseCrygd,intron B and flanking sequences, and AJ224343 for mouseCrygf,intron B and flanking sequences.
- 1
To whom correspondence should be addressed at the GSF–Research Center for Environment and Health, Institute of Mammalian Genetics, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany. Telephone: 0049-89-3187 2610. Fax: 0049-89-3187 3099. E-mail:[email protected]. Internet:http://www.gsf.de/isg/EyeDev.html.