Elsevier

Genomics

Volume 51, Issue 1, 1 July 1998, Pages 148-151
Genomics

Short Communication
Cloning of the Human Tissue Inhibitor of Metalloproteinase-4 Gene (TIMP4) and Localization of the TIMP4 andTimp4Genes to Human Chromosome 3p25 and Mouse Chromosome 6, Respectively,☆☆

https://doi.org/10.1006/geno.1998.5362Get rights and content

Abstract

We have isolated genomic DNA containing the human tissue inhibitor of metalloproteinases-4 gene (TIMP4) and determined the structure of the exons comprising the gene. Like other members of the TIMP family, the TIMP-4 protein is encoded by five exons. These span 6 kb of genomic DNA, so that TIMP4 is similar in size toTimp1but considerably smaller than TIMP2 and TIMP3. The exon–intron boundaries of TIMP4 are at locations very similar to those of the other TIMP genes, demonstrating the high degree of conservation of gene structure in this family. The human and mouse TIMP-4 genes map to comparable locations in the respective genomes, localizing to human chromosome 3p25 and mouse chromosome 6.

Cited by (34)

  • Contribution of TIMP4 rs3755724 polymorphism to susceptibility to focal epilepsy in Malaysian Chinese

    2015, Journal of Neuroimmunology
    Citation Excerpt :

    Distinct from the matrix metalloproteinase inhibitory effect of TIMP4, this protein is involved in anti-tumor activity against gliomas and astrocytomas (Yim et al., 2013). The TIMP-4 gene is located within intron 5 of the synapsin 2 (SYN2) gene; hence, there is a noteworthy regulatory area between these two genes (Olson et al., 1998; Groft et al., 2001). Synapsin 2, a synaptic vesicle (SV) phosphoprotein, is essential for synaptic transmission and plasticity, neuronal cell differentiation, and neuroprotection in the CNS.

  • A blood-based biomarker panel to detect acute stroke

    2014, Journal of Stroke and Cerebrovascular Diseases
    Citation Excerpt :

    Plasma levels of S100A12 were higher in patients with carotid atherosclerosis and highest in patients with most recent symptoms.26 TIMP-4 irreversibly inactivates metalloproteinases and is expressed in astrocytes, monocytes, platelets, smooth muscle cells, and endothelial cells.27-29 It is involved in regulating platelet recruitment and aggregation.29

View all citing articles on Scopus

Sequence data from this article have been deposited with the GenBank Data Library under Accession Nos. AF057528 through AF057532.

☆☆

E. Green

1

To whom correspondence should be addressed. Telephone: (216) 445 3278. Fax: (216) 445 4383. E-mail:[email protected].

View full text