Short CommunicationCloning of the Human Tissue Inhibitor of Metalloproteinase-4 Gene (TIMP4) and Localization of the TIMP4 andTimp4Genes to Human Chromosome 3p25 and Mouse Chromosome 6, Respectively☆,☆☆
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Cited by (34)
Contribution of gene polymorphisms on 3p25 to salivary gland carcinoma, ameloblastoma, and odontogenic keratocyst in the Chinese Han population
2023, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyContribution of TIMP4 rs3755724 polymorphism to susceptibility to focal epilepsy in Malaysian Chinese
2015, Journal of NeuroimmunologyCitation Excerpt :Distinct from the matrix metalloproteinase inhibitory effect of TIMP4, this protein is involved in anti-tumor activity against gliomas and astrocytomas (Yim et al., 2013). The TIMP-4 gene is located within intron 5 of the synapsin 2 (SYN2) gene; hence, there is a noteworthy regulatory area between these two genes (Olson et al., 1998; Groft et al., 2001). Synapsin 2, a synaptic vesicle (SV) phosphoprotein, is essential for synaptic transmission and plasticity, neuronal cell differentiation, and neuroprotection in the CNS.
Targeting matrix metalloproteinases in heart disease: Lessons from endogenous inhibitors
2014, Biochemical PharmacologyA blood-based biomarker panel to detect acute stroke
2014, Journal of Stroke and Cerebrovascular DiseasesCitation Excerpt :Plasma levels of S100A12 were higher in patients with carotid atherosclerosis and highest in patients with most recent symptoms.26 TIMP-4 irreversibly inactivates metalloproteinases and is expressed in astrocytes, monocytes, platelets, smooth muscle cells, and endothelial cells.27-29 It is involved in regulating platelet recruitment and aggregation.29
Association of synapsin 2 with schizophrenia in families of Northern European ancestry
2007, Schizophrenia ResearchCharacterization of the murine Timp4 gene, localization within intron 5 of the synapsin 2 gene and tissue distribution of the mRNA
2002, Biochimica et Biophysica Acta - Gene Structure and Expression
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Sequence data from this article have been deposited with the GenBank Data Library under Accession Nos. AF057528 through AF057532.
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E. Green
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