Regular ArticleA Human Homologue (BICD1) of theDrosophila Bicaudal-DGene
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Cited by (33)
Biophysical properties of dynein in vivo
2017, Dyneins: Dynein Mechanics, Dysfunction, and Disease: Second EditionNeuronal Roles of the Bicaudal D Family of Motor Adaptors
2017, Vitamins and HormonesCitation Excerpt :BICDs take part in processes like positioning of the centrosome and nucleus (Fig. 1B) (Splinter et al., 2010), which might explain their high expression throughout the organism in early development. In later life stages of many higher organisms like mammals, expression of BICD proteins is predominantly observed in organs like heart, muscle, spinal cord motor, and sensory neurons as well as brain (Baens & Marynen, 1997). In mammals, BICDs were shown to take part in cargo shuttle between Golgi and ER as well as regulation of exosomes secretion (Schlager et al., 2010) (Fig. 1A).
Structural basis for cargo binding and autoinhibition of Bicaudal-D1 by a parallel coiled-coil with homotypic registry
2015, Biochemical and Biophysical Research CommunicationsCitation Excerpt :The Drosophila BicD protein and its mammalian homologues in cultured cells, BICD1 and BICD2, were predicted to be cytoplasmic α-helical coiled-coil (CC) proteins that primarily localized to the Golgi apparatus along with dynactin at microtubule plus ends [13]. BICD proteins possess three CC regions, a N-terminal CC1, a central CC2, and a C-terminal CC3 region [14]. The N-terminal region of BICD, containing the CC1 and a portion of the CC2 regions, associates with cytoplasmic dynein [13].
Mutations in BICD2, which encodes a golgin and important motor adaptor, cause congenital autosomal-dominant spinal muscular atrophy
2013, American Journal of Human GeneticsCitation Excerpt :BICD2 (MIM 609797) is homologous to Drosophila bicaudal D (BicD), which is evolutionarily conserved from flies to humans (UniProt). Although flies have one BicD gene, mammals have two paralogous genes: BICD1 (MIM 602204), which is localized in chromosomal region 12p11.2–p11.1 and whose encoded protein is mainly expressed in brain, skeletal muscle, and heart,28 and BICD2, which is localized in chromosomal region 9q22.3 and encodes a ubiquitously expressed protein. BICD2 is a cytoplasmic conserved motor-adaptor protein involved in anterograde and retrograde transport.29
Nickel response in function of temperature differences: Effects at different levels of biological organization in Daphnia magna
2011, Comparative Biochemistry and Physiology - Part D: Genomics and ProteomicsCitation Excerpt :Cluster 9 summarizes the genes that are only induced at 14 °C, whereas cluster 2 is indicative of genes that are only induced at 26 °C (Fig. 2). Genes involved in reproductive processes were repressed due to cold treatment (14 °C) and showed a peak at 22 °C e.g. the in evolution well conserved Bic-D (bicaudal d homolog 1) gene (Baens and Marynen, 1997) which in Drosophila is illustrated to be important in eye development and oocyte growth (Oh and Steward, 2001) and several vitellogenin genes (cluster 1 and 7) involved in lipid transport and energy supply to the developing embryo. Since this peak of expression values at 22 °C nicely accords with the maximum reproductive success of the organisms at this temperature it was hypothesized that also other genes displaying similar patterns of expression (o.a. the genes included in the same clusters as the Vtg-genes, clusters 1 and 7 in Fig. 2) could have supportive roles in the development of the embryos and the production of offspring.
A novel protease-activated receptor-1 interactor, bicaudal D1, regulates G protein signaling and internalization
2010, Journal of Biological ChemistryCitation Excerpt :BICD has long been known as an essential developmental gene in Drosophila oocytes. Mutations in BICD disrupt the polarity of the early embryo, which results in the formation of the Bicaudal or double abdomen phenotype (31). BicD1 was found to transport mRNA transcripts and regulate retrograde transport of vesicles from the Golgi to the endoplasmic reticulum (24, 25).
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