Elsevier

Genomics

Volume 36, Issue 3, 15 September 1996, Pages 539-542
Genomics

Short Communication
Genomic Imprinting and Chromosomal Localization of the HumanMESTGene

https://doi.org/10.1006/geno.1996.0502Get rights and content

Abstract

We have isolated a human homologue (MEST) of the mouse mesoderm-specific transcript (Mest) gene that shares about 70% nucleotide sequence homology. Northern blot analysis showed that theMESTgene was expressed in all major fetal organs and tissues so far examined, i.e., amnion, brain, heart, lung, stomach, gut, adrenal, kidney, muscle, and liver, which does not contradict with mesoderm-specific expression.MESTwas abundantly expressed in hydatidiform moles of androgenetic origin, whereas it was barely detectable in dermoid cysts of parthenogenetic origin. Thus, it seems likely that theMESTgene, mapped to 7q32 by fluorescencein situhybridization, is maternally repressed as the mouse homologue.

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Sequence data from this article have been deposited with the GenBank/EMBL Data Libraries under Accession No. D78611.

1

To whom correspondence should be addressed at Research Center for Molecular Genetics, Hokkaido University, Kita 10 Nishi 8, Kita-ku, Sapporo 060, Japan. Telephone: +81-11-706-3588. Fax: +81-11-737-0536.

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