Regular ArticleCharacterization of a Highly Conserved Human Homolog to the Chicken Neural Cell Surface Protein Bravo/Nr-CAM That Maps to Chromosome Band 7q31☆
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The role of NrCAM in neural development and disorders-Beyond a simple glue in the brain
2012, Molecular and Cellular NeuroscienceCitation Excerpt :The first three exons and introns are spread over 200 kb, which may contain regulatory sequences for the expression of NrCAM, ensuring specific spatial and temporal expression patterns (Williams et al., 2006). NrCAM undergoes extensive splicing events that produce several different isoforms (Ishiguro et al., 2006; Lane et al., 1996; Wang et al., 1998). The most prominent splicing is a 93 amino acid deletion in the fifth Fn type III repeat, resulting in the prevalent form of NrCAM in the brain that has only four, instead of five Fn type III repeats.
Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains
2008, Neuroscience ResearchAlternative mRNA splicing in colon cancer causes loss of expression of neural cell adhesion molecule
2001, SurgeryCitation Excerpt :A secreted form of NCAM has been identified that results from insertion of a stop codon after exon 12.31 Bravo, an adhesion molecule with 6 immunoglobulins and 5 FN-III domains, also exhibits numerous splice variants with insertions between the 2 membranes proximal to the FN-III domains.32 Other molecules similar to NCAM , such as those deleted in colon cancer, L1,33 contactin,34 and fasciclin,35 have a variable number of FN-III repeat elements between the immunoglobulin domains and the plasma membrane.
Alternative splicing of human NrCAM in neural and nonneural tissues
1998, Molecular and Cellular Neurosciences
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Sequence data from this article have been deposited with the GenBank/EMBL Data Libraries under Accession No. U55258.
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