Regular ArticleDNA Binding and Transactivating Properties of the Paired and Homeobox Protein Pax4
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Cited by (23)
Are Pax proteins potential therapeutic targets in kidney disease and cancer?
2018, Kidney InternationalCitation Excerpt :These domains impart positive or negative transcription regulation depending on cellular context and the availability of cofactors. The carboxy-terminal domain confers transcription activation potential to most of the Pax family members8–14 and can be phosphorylated at multiple serines and threonines.15 The octapeptide is evolutionarily related to the Drosophila engrailed family Eh1 repression domain16 and can bind with the Groucho/Tle (Transducin-like enhancer of split) family of corepressors.17
Pax factors in transcription and epigenetic remodelling
2015, Seminars in Cell and Developmental BiologyCitation Excerpt :The modalities and structural constraints for recognition of such composite motifs remain poorly analysed. In most Pax proteins, transactivation domains where identified in the C-terminal part of the protein, i.e. downstream of the DBD [46–50]. However, these transactivation domains were not mapped very precisely but a number of co-activators recruited by Pax factors have been identified (Fig. 5).
A novel pax-like protein involved in transcriptional activation of cyst wall protein genes in Giardia lamblia
2010, Journal of Biological ChemistryCitation Excerpt :They may cooperate to bind DNA, and the binding sequences of Pax proteins include the two juxtaposed or overlapped sites, one recognized by the homeodomain and the other by the paired domain (46). The RED subdomain, which has more variety than the PAI subdomain, may contribute to a different sequence specificity of Pax proteins (39). Because Pax proteins play critical roles in development and cell differentiation of many eukaryotes, we asked whether Giardia has Pax family proteins and whether they influence gene expression during Giardia differentiation into dormant cysts.
Pax4 regulatory elements mediate beta cell specific expression in the pancreas
2001, Mechanisms of DevelopmentActivin A increases Pax4 gene expression in pancreatic β cell lines
2000, FEBS LettersPax4 represses pancreatic glucagon gene expression
2000, Molecular Cell Biology Research Communications
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To whom correspondence should be addressed at Institute of Molecular Genetics, Vı́deňská 1083, Prague 4, 142 20, Czech Republic. Fax: (+4202) 44471707. E-mail: [email protected].
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Biochemical Instrumentation Programme, European Molecular Biology Laboratory, Heidelberg, Germany.