Regular ArticleExpression of Endoglin mRNA and Protein in Human Vascular Smooth Muscle Cells☆
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2011, Best Practice and Research: Clinical HaematologyCitation Excerpt :Typically pericytes are positive for CD13, NG2, desmin, αSMA, PDGFRβ, CD146 (human) and for the species-specific 3G5 antibody staining (human and bovine) [50,53,56,77–79]. However, none of these markers are pan-pericyte markers, as already mentioned, with CD13, NG2, desmin, αSMA, PDGFRβ and CD146 also being expressed in VSMCs [60–65]. Moreover, the expression of some of these markers is dynamic and varies between tissues.
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2008, Trends in Cardiovascular MedicineCitation Excerpt :Elevated endoglin expression levels are used as a marker of tumor angiogenesis and endoglin antibodies coupled with toxins or radioactivity have been successfully used to target ECs in antiangiogenic therapy (Fonsatti et al. 2003, Duff et al. 2003). Other sites of expression include hematopoietic cells (Rokhlin et al. 1995, Buhring et al. 1991, Lastres et al. 1996, Pierelli et al. 2001), syncytiotrophoblast of term placenta (Gougos et al. 1992), stromal cells (Robledo et al. 1996), and mesenchymal cells (fibroblasts and vascular smooth muscle cells (VSMCs) (Adam et al. 1998, Conley et al. 2000, Ma et al. 2000, Chen et al. 2004, Mancini et al. 2007). Endoglin is a homodimer composed of 633 amino acid subunits that belongs to the zona pellucida (ZP) family of proteins that also includes betaglycan (Figure 1A).
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Abbreviations used: VSMCs, vascular smooth muscle cells; TGFβ, transforming growth factor beta; RT-PCR, reverse transcription polymerase chain reaction; HHT, hereditary hemorrhagic telangiectasia
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