Management proposals.
| Breast cancer genes | ||
| Gene | Breast cancer risk management | References |
| ATM*† | 12–18 monthly mammography from 40 to 50 depending on family history, then NHSBSP For c.7271T>G consider BRCA-equivalent | Ataxia-telangiectasia in children: guidance on diagnosis and clinical care18 Protocols for the surveillance of women at higher risk of developing breast cancer, Public Health England19 |
| BRCA1 | As per national guidelines | NICE CG16420 |
| BRCA2 | As per national guidelines | NICE CG16420 |
| CHEK2†‡ | 12-monthly mammography from 40 to 50, then NHSBSP For homozygotes consider BRCA-equivalent | Tung et al 21 |
| PALB2† | Consider BRCA-equivalent | Tung et al 21 |
| PTEN§ | Consider BRCA-equivalent | UK-CGG guidelines for management of tumour risk in PTEN hamartoma syndrome22 |
| STK11 | Consider BRCA-equivalent | Beggs et al 23 |
| TP53 | As per national guidelines | NICE CG16420 |