Table 3

Association results for all 33 fatty acid phenotypes and SNPs with MAF>0.01 at the chromosome 11 FADS1/2/3 locus, ordered by descending maternal test significance with P value <1.0×10−9

GeneSNPPositionRefAAltARAFβ*SE β*Maternal
P value
FADS1rs17455661580635tc0.170.851.0251.5×10−10
FADS1, MIR1908rs17456161582708tc0.831.171.0251.7×10−10
FADS1rs17454961571382ag0.170.851.0251.7×10−10
FADS1rs17455561579760tc0.831.171.0251.7×10−10
FADS1rs174557†61581368ag0.831.171.0251.8×10−10
FADS1rs174544†61567753ac0.170.851.0251.8×10−10
FADS2rs2845661589481ag0.831.171.0252.3×10−10
FADS1rs17456061581764tc0.831.171.0252.3×10−10
FADS1rs17454861571348cg0.831.171.0252.3×10−10
FADS2rs17457861605499at0.190.861.0253.9×10−10
FADS2rs17457761604814ac0.190.861.0253.9×10−10
FADS2rs17456861593816tc0.180.861.0257.1×10−10
FADS1rs17455061571478tc0.821.161.0257.8×10−10
FADS1rs17454661569830tc0.180.861.0257.8×10−10
FADS1rs17454561569306cg0.821.161.0257.8×10−10
FADS1rs17454761570783tc0.821.161.0257.8×10−10
FADS1rs17455161573684tc0.821.161.0257.9×10−10
FADS1rs174553†61575158ag0.821.161.0258.0×10−10
FADS2rs17458161606683ag0.190.871.0258.3×10−10
FADS2rs774882452†61594920ctc0.821.161.0259.2×10−10
FADS2rs3547359161586328ctc0.180.861.0259.3×10−10
FADS2rs17456261585144ag0.821.161.0259.5×10−10
  • The 22 highest ranked SNPs were all for log(AA) phenotype, but only those with P<1×10−9 are shown (22 in total).

  • All meta-analysis effect directions were consistent between the two studies for all SNPs with maternal P value <0.018.

  • *Exponentiated values from the log (FA fraction) model in mothers and hence the multiplicative change in the fractional composition of the FA per reference allele. 

  • †SNPs were imputed with an information content >0.99 and <1; all others had info=1.

  • AA, arachidonic acid; FA, fatty acid; FADS2, fatty acid desaturase 2.