Gene | SNP | Position | RefA | AltA | RAF | β* | SE β* | Maternal P value |
FADS1 | rs174556 | 61580635 | t | c | 0.17 | 0.85 | 1.025 | 1.5×10−10 |
FADS1, MIR1908 | rs174561 | 61582708 | t | c | 0.83 | 1.17 | 1.025 | 1.7×10−10 |
FADS1 | rs174549 | 61571382 | a | g | 0.17 | 0.85 | 1.025 | 1.7×10−10 |
FADS1 | rs174555 | 61579760 | t | c | 0.83 | 1.17 | 1.025 | 1.7×10−10 |
FADS1 | rs174557† | 61581368 | a | g | 0.83 | 1.17 | 1.025 | 1.8×10−10 |
FADS1 | rs174544† | 61567753 | a | c | 0.17 | 0.85 | 1.025 | 1.8×10−10 |
FADS2 | rs28456 | 61589481 | a | g | 0.83 | 1.17 | 1.025 | 2.3×10−10 |
FADS1 | rs174560 | 61581764 | t | c | 0.83 | 1.17 | 1.025 | 2.3×10−10 |
FADS1 | rs174548 | 61571348 | c | g | 0.83 | 1.17 | 1.025 | 2.3×10−10 |
FADS2 | rs174578 | 61605499 | a | t | 0.19 | 0.86 | 1.025 | 3.9×10−10 |
FADS2 | rs174577 | 61604814 | a | c | 0.19 | 0.86 | 1.025 | 3.9×10−10 |
FADS2 | rs174568 | 61593816 | t | c | 0.18 | 0.86 | 1.025 | 7.1×10−10 |
FADS1 | rs174550 | 61571478 | t | c | 0.82 | 1.16 | 1.025 | 7.8×10−10 |
FADS1 | rs174546 | 61569830 | t | c | 0.18 | 0.86 | 1.025 | 7.8×10−10 |
FADS1 | rs174545 | 61569306 | c | g | 0.82 | 1.16 | 1.025 | 7.8×10−10 |
FADS1 | rs174547 | 61570783 | t | c | 0.82 | 1.16 | 1.025 | 7.8×10−10 |
FADS1 | rs174551 | 61573684 | t | c | 0.82 | 1.16 | 1.025 | 7.9×10−10 |
FADS1 | rs174553† | 61575158 | a | g | 0.82 | 1.16 | 1.025 | 8.0×10−10 |
FADS2 | rs174581 | 61606683 | a | g | 0.19 | 0.87 | 1.025 | 8.3×10−10 |
FADS2 | rs774882452† | 61594920 | ct | c | 0.82 | 1.16 | 1.025 | 9.2×10−10 |
FADS2 | rs35473591 | 61586328 | ct | c | 0.18 | 0.86 | 1.025 | 9.3×10−10 |
FADS2 | rs174562 | 61585144 | a | g | 0.82 | 1.16 | 1.025 | 9.5×10−10 |
The 22 highest ranked SNPs were all for log(AA) phenotype, but only those with P<1×10−9 are shown (22 in total).
All meta-analysis effect directions were consistent between the two studies for all SNPs with maternal P value <0.018.
*Exponentiated values from the log (FA fraction) model in mothers and hence the multiplicative change in the fractional composition of the FA per reference allele.
†SNPs were imputed with an information content >0.99 and <1; all others had info=1.
AA, arachidonic acid; FA, fatty acid; FADS2, fatty acid desaturase 2.