Genome-wide significant SNP identified in GWAS for sperm motility
| SNP (effect/reference) | Chr. | Position (hg 19) | Gene locus | Stage | Genotype | EAF | Beta (SE) | P value | Var (%)* |
| rs3791686 (C/T) | 2 | 212 221 870 | ERBB4 intron | Discovery | 40/307/464 | 0.24 | −4.25 (0.84) | 4.47×10−7 | |
| Replication | 48/268/463 | 0.23 | −3.51 (1.21) | 3.88×10−3 | |||||
| Meta-analysis | −4.01 (0.69) | 5.40×10−9 | 2.0 |
Data are shown as the estimated linear regression statistic beta, SE and P value using an additive genetic model with adjustments for age, BMI, ejaculation abstinence and time from masturbation to test.
*Var (%): percentage of phenotypic variance explained by SNP.
BMI, body mass index; Chr, chromosome; EAF, effect allele frequency; GWAS, genome-wide association study; SNP, single nucleotide polymorphism.