Overall BC risk estimates for truncating mutations in each gene. Variant category tallies (online supplementary table S4) and carrier counts (online supplementary table S5) are available in the supplementary materials
| Cases | Controls | OR (95% CI) | P-Value | |||||
| Carriers | Non-Carriers | Carriers Frequency | Carriers | Non-Carriers | Carrier Frequency | |||
| ATM | 85 | 13,002 | 0.00649 | 11 | 5,477 | 0.00200 | 3.26 (1.82–6.46) | 2.1×10-5 |
| CHEK2 | 213 | 12,874 | 0.01628 | 29 | 5,459 | 0.00528 | 3.11 (2.15–4.69) | 5.6×10-11 |
| PALB2 | 89 | 12,998 | 0.00685 | 8 | 5,480 | 0.00146 | 4.69 (2.27–9.68) | 6.9×10-6 |
| XRCC2 | 9 | 13,078 | 0.00069 | 4 | 5,484 | 0.00073 | 0.94 (0.26–4.19) | 0.92 |