Table 2

Proportion of sporadic ovarian/HGS and sporadic breast cancer/triple negative with BRCA1/2 mutations

Age of diagnosisSporadic ovarianSporadic HGS ovarianSporadic breast cancerSporadic TNT
<30Mutation0054
Number tested628026
BRCA1/2 %0.00.06.2515.4
30–39 Mutation1174
Number tested12817987
%8.312.53.94.6
40–49 Mutation5522
Number tested51435424
%9.811.63.78.3
50–59 Mutation9911
Number tested6460244
%14.115.04.225.0
60+ Mutation0000
Number tested181631
%0.00.00.00.0
Total mutated15151511
Total tested151129340142
%9.911.64.47.75
BRCA1 11111010
% 7.288.52.97.0
BRCA2 4451
% 2.653.11.50.7
  • 2/8 adopted patients with triple-negative breast cancer with BRCA1 mutations were excluded from the analysis.

  • HGS, high-grade serous; TNT, triple-negative tumour.