Table 2

Associations by family history, synchronous or metachronous bilateral disease, age at diagnosis and hormone receptor subtype. 

ATMCHEK2PALB2
All CasesCarriersOR (95%CI)P-ValueCarriersOR (95%CI)P-ValueCarriersOR (95%CI)P-Value
Family History*
Positive1,301 (17.0%)16 (29.6%)28 (23.5%)7 (13.2%)
Negative6,330 (83.0%)38 (70.4%)2.06 (1.12-3.65)0.02291 (76.5%)1.51 (0.97-2.28)0.07046 (86.8%)0.74 (0.60-1.54)0.44
Bilateral Disease*
Positive220 (1.7%)0 (0.0%)11 (5.3%)4 (4.7%)
Negative12,526 (98.3%)83 (100.0%)NA0.089198 (94.7%)3.27 (1.66-5.83)0.001481 (95.3%)2.85 (0.86-6.91)0.080
Age at Diagnosis*
Before 503,674 (28.4%)25 (29.8%)3.41 (1.72-7.23)76 (36.0%)3.98 (2.62-6.21)27 (31.4%)5.80 (2.67-14.5)
50s4,952 (38.3%)34 (40.5%)3.44 (1.80-7.13)87 (41.2%)3.37 (2.24-5.22)41 (47.7%)6.54 (3.12-16.0)
After 604,305 (33.3%)25 (29.8%)2.91 (1.47-6.17)0.6648 (22.7%)2.12 (1.35-3.41)1.2x10-518 (20.9%)3.29 (1.43-8.47)0.22
ER Status†
Positive7,845 (83.6%)50 (92.6%)3.19 (1.73-6.47)1.0x10-4140 (91.5%)3.42 (2.33-5.21)1.5x10-1143 (79.6%)4.32 (2.07-10.5)2.7x10-5
Negative1,544 (16.4%)4 (7.4%)1.28 (0.36-3.76)0.6713 (8.5%)1.59 (0.80-3.00)0.1811 (20.4%)5.58 (2.19-15.2)3.6x10-4
PR Status†
Positive3,026 (66.5%)16 (64%)2.65 (1.24-5.87)0.01261 (81.3%)3.87 (2.51-6.12)4.3E-1016 (57.1%)4.16 (1.77-10.8)9.0x10-4
Negative1,524 (33.5%)9 (36%)2.96 (1.19-7.16)0.02114 (18.7%)1.75 (0.89-3.25)0.10012 (42.9%)6.21 (2.5-16.7)1.0x10-4
  • *Case only analysis.

  • †Case-control analysis.