Adjusted regression analyses of all participants by sex
| Variable | Beta coefficient† | 95% CI‡ | p Value |
|---|---|---|---|
| (A) Men, interaction model, n=137, intercept=418.4 ms, adjusted R2=0.54 | |||
| V205M | 29.3 | 19.2 to 39.4 | <0.001 |
| L353L | 14.0 | 2.9 to 25.1 | 0.014 |
| K897T | 5.7 | −19.3 to 30.7 | 0.651 |
| V205M*L353L | 34.6 | 12.0 to 57.2 | 0.003 |
| L353L*K897T | – | ||
| V205M*K897T | – | ||
| V205M*L353L*K897T | – | ||
| (B) Women, interaction model, n=282, intercept=444.3 ms, adjusted R2=0.28 | |||
| V205M | 31.5 | 20.1 to 42.9 | <0.001 |
| L353L | 10.0 | −0.6 to 20.6 | 0.064 |
| K897T | −4.2 | −16.1 to 7.6 | 0.481 |
| V205M*L353L | −14.5 | −42.6 to 13.7 | 0.312 |
| V205M*K897T | −27.2 | −43.1 to -11.3 | 0.001 |
| L353L*K897T | 29.9 | 4.7 to 55.0 | 0.020 |
| V205M*L353L*K897T | −14.0 | −51.3 to 23.3 | 0.461 |
| (C) Men and women, interaction model, n=419, intercept=422.3 ms, adjusted R2=0.40 | |||
| V205M | 30.0 | 21.8 to 38.3 | <0.001 |
| L353L | 11.2 | 3.1 to 19.3 | 0.007 |
| K897T | −0.6 | −11.7 to 10.5 | 0.914 |
| V205M*L353L | 7.2 | −17.4 to 31.5 | 0.558 |
| V205M*K897T | −26.7 | −40.5 to −12.8 | <0.001 |
| L353L*K897T | 19.3 | −6.5 to 45.1 | 0.142 |
| V205M*L353L*K897T | −25.9 | −60.0 to 8.2 | 0.136 |
†Beta coefficients from OLS linear regression representing the baseline (intercept) and change in QTc (ms). Model was adjusted for age, past and current alcohol abuse, QT-prolonging drug use, cardiovascular disease and indicator variable for interpolated QTc.
‡95% CI using robust SEs.
QTc, corrected QT.