Table 2

Most significant independent loci in the genome-wide interaction analysis between tricyclic antidepressants and RR interval

SNP	CHR	Mapped gene	Ethnicity	EAF	N studies	Effect allele	β_int	SE_int	p_int	p_het
rs6737205	2	BRE	EA	0.94	4	A	56.3	9.7	7.66e⁻⁹	0.16
			AA	Did not pass quality control
			HSP	Did not pass quality control
rs9830388	3	UBE2E2	EA	0.51	14	A	25.2	4.5	1.72e⁻⁸	0.44
			AA	0.30	5	A	18.1	11.5	0.11	0.72
			HSP	0.55	2	A	−8.2	12.4	0.51	0.44
rs11867129	16	ABCA3	EA	0.09	11	T	35.7	6.9	2.57e⁻⁷	0.05
			AA	Did not pass quality control
			HSP	0.41	2	T	4.5	13.5	0.74	0.12

Only independent genetic variants with a p value for interaction below 5e⁻⁷ are displayed.
AA, African-Americans; ABCA3, ATP binding cassette subfamily A member 3; BRE, brain and reproductive organ-expressed; CHR, chromosome; EA, Europeans; EAF, effective allele frequency; HSP, Hispanic/Latinos; N, number of studies included in the meta-analysis after quality control. p_het, p value for heterogeneity between studies; p_int, p value of the interaction; SE_int, SE of the interaction; UBE2E2, ubiquitin conjugating enzyme E2E 2.