Adjusted predicted margins and multiple pairwise comparisons
| Variant status of participants | Sample size | Margin (QTc) | Delta-method SE | Unadjusted groups | Bonferroni groups |
|---|---|---|---|---|---|
| (A) Men† | |||||
| Negative for all variants | 91 | 426.4 | 2.6 | A | A |
| L353L | 15 | 440.4 | 4.9 | B | AB |
| V205M | 21 | 455.8 | 4.1 | C | B |
| V205M*L353L | 5 | 504.4 | 9.1 | D | C |
| (B) Women‡ | |||||
| Negative for all variants | 169 | 448.4 | 1.9 | A | A |
| K897T | 18 | 444.0 | 5.7 | A | A |
| L353L | 40 | 458.1 | 4.9 | AB | AB |
| L353L*K897T | 3 | 483.2 | 10.0 | C | B |
| V205M | 40 | 479.2 | 5.1 | C | B |
| V205M*K897T | 3 | 447.5 | 2.6 | A | A |
| V205M*L353L | 7 | 474.5 | 12.2 | BC | AB |
| V205M*L353L*K897T | 2 | 459.0 | 4.0 | B | AB |
| (C) Men and women combined‡ | |||||
| Negative for all variants | 260 | 441.2 | 1.5 | A | A |
| K897T | 23 | 440.4 | 5.4 | AB | AB |
| L353L | 55 | 452.1 | 3.7 | BC | AB |
| L353L*K897T | 3 | 470.4 | 11.0 | CD | ABC |
| V205M | 61 | 470.5 | 3.6 | D | C |
| V205M*K897T | 3 | 443.1 | 2.9 | AB | AB |
| V205M*L353L | 12 | 488.8 | 11.0 | D | C |
| V205M*L353L*K897T | 2 | 455.0 | 3.8 | C | BC |
Margins sharing a letter in the group label are not significantly different at the 5% level.
*Adjusted for six comparisons' should be preceded by only 1 symbol (as seen above for men)
†Adjusted for six comparisons.
‡Adjusted for 28 comparisons.
QTc, corrected QT.