Poisson regression analysis of eGFR slope at −2.0 mL/min/1.73 m2/year for 18 participants who met the UCPR goal
| Variable | Relative risk | 95% CI | p Value |
|---|---|---|---|
| Age: ERT started (years) | 1.072 | 1.008 to 1.139 | 0.026 |
| Interval: ERT start to visit 0 (years) | 0.881 | 0.771 to 1.006 | 0.062 |
| Average systolic blood pressure (mm Hg) | 1.011 | 0.991 to 1.033 | 0.287 |
| Average UPCR during treatment (mg/g) | 1.479 | 0.630 to 3.468 | 0.369 |
| Male gender | 1.130 | 0.637 to 2.005 | 0.675 |
| Medication score | 1.392 | 0.859 to 2.254 | 0.179 |
Relative risk presented as ratios (95% CI). Medication score defined as: 0, none; 1, ACE inhibitor or ARB; 2, ACE inhibitor plus ARB, or diuretic; 3, ACE inhibitor or ARB at maximum dose. p<0.05 for risk ratios from Poisson regression model (shown in bold).
ARB, angiotensin type 1 receptor blocker; eGFR, estimated glomerular filtration rate; ERT, enzyme replacement therapy; UPCR, urinary protein to creatinine ratio (g/g).