Table 1

Cumulative effect of 28 risk alleles on anthropometric measures

Age	Outcome	N	Coefficient*	95% CI	p Value
Cross-sectional analysis
Birth	zBW	1237	0.008	−0.011 to 0.026	0.422
2 years†	zWT	1820	0.012	−0.003 to 0.027	0.134
2 years†	zHT	1820	0.009	−0.006 to 0.025	0.246
≤20 years	zWT-HT	2211	0.008	−0.002 to 0.017	0.108
Adults‡	zWT	1426	0.018	0.001 to 0.035	0.034
Adults‡	zHT	1426	0.004	−0.012 to 0.021	0.609
>20 years	zWT-HT	1426	0.025	0.007 to 0.044	0.006
Adults‡	zBMI	1426	0.016	−0.001 to0.034	0.060
Longitudinal analysis
0–2 years	WT growth	1248	0.001	−0.009 to 0.012	0.810
0–2 years	LG growth	1214	0.005	−0.000 to 0.011	0.064
2–20 years	zWT change	872	0.010	−0.016 to 0.035	0.455
2–20 years	zHT change	872	0.006	−0.020 to 0.032	0.666

*Coefficients indicate change in z-scores per allele (cross-sectional) or change in z-scores per allele per year (longitudinal).
†Nearest observation to 2 years of age (>1.5 and <2.5 years).
‡First measurement at adult age (>20 years).
BMI, body mass index; BW, birthweight; HT, height; LG, length; WT, weight; zBMI, BMI z-score; zBW, BW z-score; zHT, height-for-age z-score; zWT, weight-for-age z-score; zWT-HT, weight-for-height z-score.
Results significant at the p<0.05 level are indicated in bold.