Table 4

Haplotype diversity analysis of absorption, distribution, metabolism and excretion genes. Shown here are genes with at least three functional SNPs defined by PharmaGKB

Gene	Number of SNPs	Hd_CHB	Hd_HUI	Hd_KGZ	Hd_KZK	Hd_UIG	Hd_TJK	Hd_CEU	p Value
ABCA1	3	0.806	0.799	0.760	0.714	0.760	0.666	0.479	0.001
ABCB1	6	0.633	0.718	0.635	0.687	0.667	0.688	0.691	0.028
ABCC1	4	0.701	0.647	0.630	0.594	0.610	0.648	0.558	0.001
ABCC2	7	0.780	0.701	0.821	0.796	0.820	0.828	0.797	0.070
ABCC4	4	0.679	0.698	0.648	0.674	0.713	0.723	0.657	0.144
ABCG2	4	0.765	0.776	0.655	0.644	0.665	0.622	0.531	0.001
CYP1A2	3	0.676	0.701	0.676	0.665	0.706	0.626	0.501	0.001
CYP2C8	3	0.479	0.452	0.418	0.510	0.475	0.567	0.494	0.082
CYP39A1	3	0.364	0.490	0.390	0.485	0.617	0.690	0.530	0.001
NAT2	3	0.353	0.476	0.552	0.552	0.689	0.701	0.690	0.001
SLC10A2	3	0.793	0.719	0.799	0.808	0.776	0.761	0.740	0.001
SLC22A14	3	0.478	0.442	0.347	0.445	0.489	0.408	0.418	0.104
SLCO1B1	4	0.620	0.459	0.440	0.558	0.421	0.424	0.501	0.000
UGT1A10	3	0.425	0.453	0.381	0.535	0.536	0.530	0.495	0.070
UGT1A6	3	0.425	0.453	0.381	0.535	0.536	0.530	0.495	0.024
UGT1A7	3	0.425	0.453	0.381	0.535	0.536	0.530	0.495	0.018
UGT1A8	3	0.425	0.453	0.381	0.535	0.536	0.530	0.495	0.024
UGT1A9	3	0.425	0.453	0.381	0.535	0.536	0.530	0.495	0.028

HUI, Hui; KGZ, Kirgiz; KZK, Kazakh; TJK, Tajik; UIG, Uyghur.