Table 5

Highly differentiated functional SNPs in absorption, distribution, metabolism and excretion core genes between CEU and CHB (empirical p<0.01). Shown here are SNPs based on the 1000 Genomes Project, but data are not available in our genotyping data or in the HapMap III dataset

rsID	Gene	F_ST	f_CEU	f_CHB	Function	Type	Substrate
rs2231164	ABCG2	0.194	0.912	0.505	Intron	NF_ASS	Antineoplastic
rs13120400	ABCG2	0.161	0.265	0.000	Intron	NF_ASS	Methotrexate
rs4646421	CYP1A1	0.142	0.088	0.423	Intron	F_ASS	Caffeine
rs2606345	CYP1A1	0.438	0.682	0.052	Intron	NF_ASS	Carbamazepine
rs3826041	CYP1A1	0.140	0.877	0.531	Upstream	F_NAS	–
rs2470893	CYP1A1	0.225	0.353	0.000	Upstream	NF_ASS	Caffeine
rs2472304	CYP1A2	0.318	0.659	0.113	Intron	NF_ASS	Caffeine
rs146991580	CYP2D6	0.142	0.229	0.603	Non-synonymous	F_N	–
rs9419082	CYP2E1	0.171	0.894	0.510	Intron	F_NAS	–
rs8192766	CYP2E1	0.149	0.894	0.541	Upstream	NF_ASS	Caffeine
rs4646458	CYP3A5	0.146	0.988	0.706	Downstream	NF_ASS	Tacrolimus
rs1801280	NAT2	0.245	0.424	0.021	Non-synonymous	F_NAS	–
rs2306283	SLCO1B1	0.154	0.588	0.206	Non-synonymous	F_ASS	Mycophenolate
rs2417966	SLCO1B1	0.320	0.788	0.222	Intron	F_NAS	–
rs10034124	UGT2B17	0.150	0.071	0.407	Intergenic	F_NAS	–
rs7435827	UGT2B17	0.130	0.706	0.345	Intron	F_NAS	–
rs7434408	UGT2B17	0.215	0.665	0.206	Intron	F_NAS	–